MA5-15444 targets EP300 in WB applications and shows reactivity with Human samples.
The MA5-15444 immunogen is purified recombinant fragment of EP300 expressed in E. Coli.
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A , and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
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Protein Aliases: E1A-associated protein p300; E1A-binding protein, 300kD; EP300; Histone acetyltransferase p300; Histone butyryltransferase p300; Histone crotonyltransferase p300; KAT3B; p300 HAT; Protein propionyltransferase p300
Gene Aliases: EP300; KAT3B; P300; RSTS2
UniProt ID: (Human) Q09472
Entrez Gene ID: (Human) 2033