p38 MAPK alpha (MAPK14), p38 MAPK beta (MAPK11), and p38 MAPK delta (MAPK13) are serine/threonine kinases which act as an essential component of the MAPkinase signal transduction pathway. p38 MAPK alpha, p38 MAPK beta, and p38 MAPK delta are three of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets.
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Protein Aliases: CRK1; CSAID-binding protein; Csaids binding protein; cytokine suppressive anti-inflammatory drug binding protein; cytokine suppressive anti-inflammatory drug binding protein 1; Cytokine suppressive anti-inflammatory drug-binding protein; cytokine-supressive anti-inflammatory drug binding protein; MAP kinase 11; MAP kinase 13; MAP kinase 14; MAP kinase 2; MAP kinase MXI2; MAP kinase p38 alpha; MAP kinase p38 beta; MAP kinase p38 delta; MAPK 11; MAPK 13; MAPK 14; MAX-interacting protein 2; mitogen activated protein kinase 11; mitogen activated protein kinase 13; mitogen activated protein kinase 14; Mitogen-activated protein kinase 11; Mitogen-activated protein kinase 13; Mitogen-activated protein kinase 14; mitogen-activated protein kinase 14A; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase p38 beta; Mitogen-activated protein kinase p38 delta; mitogen-activated protein kinase p38-2; p38 alpha; p38 delta MAP kinase; p38 MAP kinase; p38 MAP kinase alpha; p38 MAPK; p38 mitogen activated protein kinase; p38-2; p38alpha Exip; protein kinase, mitogen activated kinase, 11, p38beta; reactive kinase; SAPK/Erk/kinase 4; SAPK2a; SAPK2b; Stress-activated protein kinase 2a; Stress-activated protein kinase 2b; Stress-activated protein kinase 4; stress-activated protein kinase-2; stress-activated protein kinase-2b; tRNA synthetase cofactor p38
Gene Aliases: CRK1; CSBP; CSBP1; CSBP2; CSPB1; EXIP; Hog; MAPK 13; MAPK-13; MAPK11; MAPK13; MAPK14; MXI2; p38; p38-2; p38-alpha; p38a; p38ALPHA; P38B; p38Beta; P38BETA2; p38delta; p38Hog; p38MAPK; PRKM11; PRKM13; PRKM14; PRKM15; RK; SAPK2; SAPK2A; SAPK2B; SAPK4; Serk4