Recommended positive controls: A549, HeLa, HepG2, HCT116.
Predicted reactivity: Mouse (97%), Rat (96%), Xenopus laevis (85%), Pig (99%), Chicken (90%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase.
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Protein Aliases: actin related protein 2/3 complex subunit 1B, 41kDa; actin related protein 2/3 complex, subunit 1B, 41kDa; Actin-related protein 2/3 complex subunit 1B; Arp2/3 complex 41 kDa subunit; ARP2/3 protein complex subunit p41; OTTHUMP00000206020; p41-ARC
Gene Aliases: ARC41; ARPC1B; p40-ARC; p41-ARC
UniProt ID: (Human) O15143
Entrez Gene ID: (Human) 10095