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Fabgennix

p75 NGF Receptor Polyclonal Antibody

View all (81) NGFR (CD271) antibodies

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Product Details

P75NTR-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (IHC)

1:50-1:250
-

Immunocytochemistry (ICC/IF)

1:50-1:250
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-

Immunomicroscopy (IM)

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on P-75NTR protein.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD271; CD271 antigen; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor, fast; NGF receptor; p-75; p75 ICD; p75 neurotrophin receptor; p75 ntr; TNFR superfamily, member 16; TNR16; Tumor necrosis factor receptor superfamily member 16; unnamed protein product

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Gene Aliases: CD271; Gp80-LNGFR; LNGFR; NGFR; p75; p75(NTR); p75NGFR; p75NTR; RNNGFRR; TNFRSF16

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UniProt ID: (Human) P08138, (Rat) P07174, (Mouse) Q9Z0W1

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Entrez Gene ID: (Human) 4804, (Rat) 24596, (Mouse) 18053

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Function(s)
beta-amyloid binding transmembrane signaling receptor activity death receptor activity protein binding calmodulin binding coreceptor activity small GTPase binding ubiquitin protein ligase binding signaling receptor activity neurotrophin binding nerve growth factor binding neurotrophin TRKA receptor binding Rab GTPase binding preprotein binding transmembrane signal receptor
Process(es)
cellular glucose homeostasis hair follicle development intracellular protein transport apoptotic process signal transduction Rho protein signal transduction nervous system development axon guidance central nervous system development circadian rhythm fibroblast growth factor receptor signaling pathway regulation of gene expression detection of temperature stimulus nerve development cell differentiation negative regulation of cell migration hair follicle morphogenesis circadian regulation of gene expression dorsal aorta development negative regulation of fibroblast growth factor receptor signaling pathway regulation of cell proliferation odontogenesis of dentin-containing tooth positive regulation of odontogenesis of dentin-containing tooth glucose homeostasis positive regulation of apoptotic process skin development fibroblast proliferation positive regulation of fibroblast proliferation rhythmic process neuron apoptotic process negative regulation of hair follicle development extrinsic apoptotic signaling pathway presynaptic modulation of chemical synaptic transmission positive regulation of protein localization to nucleus positive regulation of pri-miRNA transcription from RNA polymerase II promoter negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis cellular response to beta-amyloid positive regulation of endothelial cell apoptotic process positive regulation of apoptotic signaling pathway response to wounding positive regulation of cell death negative regulation of neuron projection development programmed cell death sensory perception of pain positive regulation of myelination positive regulation of synaptic transmission, cholinergic response to lipopolysaccharide cellular response to oxidative stress positive regulation of Rho protein signal transduction skeletal muscle cell differentiation positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of protein kinase B signaling negative regulation of mitochondrial depolarization positive regulation of synaptic transmission, glutamatergic negative regulation of cell death positive regulation of neuron death regulation of reactive oxygen species metabolic process regulation of glucose import in response to insulin stimulus multicellular organism development
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