Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. ASIC1 is permeable for Ca(2+), Li(+) and K(+) and is expressed in dorsal root ganglia, sciatic nerves, olfactory bulb, neo and allocortical regions, dentate granule cells, pyramidal cells of CA1-CA3 subfields of the hippocampal formation, habenula, basolateral amygdaloid nuclei, and in the Purkinje and granule cells of the cerebellum. It is diffusely detected over most other regions of the basal ganglia, including thalamic nuclei, substantia nigra, striatum and globus pallidus, hypothalamus, midbrain, pons, medulla and choroid plexus. Isoform 3 is expressed only in dorsal root ganglion while isoform 1 is expressed in DRG, spinal chord, trigeminal ganglia and the trigeminal mesencephalic nucleus.
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Protein Aliases: acid sensing (proton gated) ion channel 1; acid sensing (proton gated) ion channel 2; acid sensing (proton gated) ion channel 3; acid sensing (proton gated) ion channel family member 4; acid sensing ion channel; acid sensing ion channel 1; acid sensing ion channel 2; acid sensing ion channel 3; acid sensing ion channel family member 4; acid-sensing (proton-gated) ion channel 1; acid-sensing (proton-gated) ion channel 2; acid-sensing (proton-gated) ion channel 3; acid-sensing (proton-gated) ion channel family member 4; Acid-sensing ion channel; Acid-sensing ion channel 1; acid-sensing ion channel 1a protein; Acid-sensing ion channel 2; Acid-sensing ion channel 3; Acid-sensing ion channel 4; Amiloride-sensitive brain sodium channel; Amiloride-sensitive brain sodium channel 2; Amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive cation channel 1, neuronal (degenerin); Amiloride-sensitive cation channel 2, neuronal; Amiloride-sensitive cation channel 3; amiloride-sensitive cation channel 3, testis; Amiloride-sensitive cation channel 4; Amiloride-sensitive cation channel 4, pituitary; amiloride-sensitive cation channel family member 4, pituitary; Amiloride-sensitive cation channel neuronal 1; ASIC1; ASIC2; ASIC3; ASIC4; BNaC2; BNC1; Brain sodium channel 1; Brain sodium channel 2; brain sodium channel 4; Cation channel, amiloride-sensitive, neuronal, 2; degenerin; degenerin 2; Dorsal root ASIC; DRASIC; hTNaC1; Mammalian degenerin homolog; MDEG; modulatory subunit of ASIC2a; neuronal amiloride-sensitive cation channel 1; Neuronal amiloride-sensitive cation channel 3; proton gated cation channel ASIC1; proton gated cation channel DRASIC; proton-gated cation channel subunit; putative acid-sensing ion channel; Spinal chord ASIC; Testis sodium channel 1
Gene Aliases: ACCN; ACCN1; ACCN2; ACCN3; ACCN4; ACIC2; AI843610; ASIC; ASIC1; ASIC1a; ASIC2; ASIC2a; ASIC3; ASIC4; AW742291; B530003N02Rik; BNAC1; BNaC1a; BNAC2; BNAC4; BNC1; BNC1k; DRASIC; hBNaC1; MDEG; MDEG1; MDEG2; SLNAC1; Spasic; TNAC1
Molecular Function: ion channel