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pan-Cytokeratin Polyclonal Antibody
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Product Details
BS-2190R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Horse,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from mouse Cytokeratin 19.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Cytokeratins, a group comprising at least 29 different proteins, are characteristic of epithelial and trichocytic cells. Cytokeratins 1, 4, 5, 6, and 8 are members of the type II neutral to basic subfamily. Antibody to cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. Anti Pan Cytokeratin (mixture) is a broadly reactive reagent, which recognizes epitopes present in most human epithelial tissues. It facilitates typing of normal, metaplastic and neoplastic cells. Synergy between the various components results in staining amplification. This enables identification of cells, which would otherwise be stained only marginally. The mixture may aid in the discrimination of carcinomas and nonepithelial tumors such as sarcomas, lymphomas and neural tumors. It is also useful in detecting micrometastases in lymph nodes, bone marrow and other tissues and for determining the origin of poorly differentiated tumors. There are two types of cytokeratins the acidic type I cytokeratins and the basic or neutral type II cytokeratins. Cytokeratins are usually found in pairs comprising a type I cytokeratin and a type II cytokeratin. Usually the type II cytokeratins are 8kD larger than their type I counterparts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 40-kDa keratin intermediate filament; Cell proliferation-inducing gene 46 protein; CK-18; CK-19; CK-42; cytokeratin 18; cytokeratin 19; Cytokeratin endo B; Cytokeratin-18; Cytokeratin-19; Cytokeratin-42; Endo B; K18; K19; K42; keratin 17n; keratin 18, type I; keratin 19, type I; keratin complex 1, acidic, gene 18; keratin complex 1, acidic, gene 19; Keratin D; Keratin, type I cytoskeletal 18; Keratin, type I cytoskeletal 19; Keratin, type I cytoskeletal 42; keratin, type I, 40-kd; Keratin-17n; Keratin-18; Keratin-19; Keratin-42; krt18 {ECO:0000250|UniProtKB:P05783}; krt42; krt42 {ECO:0000250|UniProtKB:Q6SEK1}; ORF; PIG46; predicted ortholog of type I keratin KA22; Type I keratin Ka19; Type I keratin Ka22; unnamed protein product
Gene Aliases: 2410039E07Rik; AI663979; CK-18; CK18; CK19; CYK18; ecat6; EndoC; K17n; K18; K19; K1CS; Ka19; Ka22; Kerd; Krt-1.19; Krt1-18; Krt1-19; KRT18; KRT19; Krt42; PIG46
RNA binding
structural molecule activity
protein binding
scaffold protein binding
cadherin binding involved in cell-cell adhesion
structural constituent of cytoskeleton
structural constituent of muscle
structural constituent of epidermis
macromolecular complex binding
molecular_function
poly(A) RNA binding
protein complex binding
morphogenesis of an epithelium
Notch signaling pathway
epithelial cell differentiation
response to estrogen
intermediate filament organization
sarcomere organization
cell differentiation involved in embryonic placenta development
biological_process
tumor necrosis factor-mediated signaling pathway
Golgi to plasma membrane CFTR protein transport
negative regulation of apoptotic process
intermediate filament cytoskeleton organization
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
anatomical structure morphogenesis
Golgi to plasma membrane protein transport
cell-cell adhesion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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