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pan-RAS Recombinant Rabbit Monoclonal Antibody (2I22), CoraLite® Plus 488

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pan-RAS Recombinant Rabbit Monoclonal Antibody (2I22), CoraLite® Plus 488

Product Details

CL488-81615

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

0.40 µg/10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Host/Isotype

Rabbit / IgG

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2I22

Immunogen

pan-RAS fusion protein Ag2700
3D Epitope / Immunogen

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MTEYKLVVV GAGGVGKSAL TIQLIQNHFV DEYDPTIEDS YRKQVVIDGE TCLLDILDTA GHEEYSAMRD QYMRTGEGFL CVFAINNTKS FEDIHHYREQ IKRVKDSEDV PMVLVGNKCD LPSRTVDTKQ AQDLARSYGI PFIETSAKTR QGVDDAFYTL VREIRKHKEK MSKDGKKKKK KSKTKCVIM

Target Information

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-Ha-ras p21 protein; c-Ha-ras transgene; c-has/bas p21 protein; c-K-ras; c-K-ras2 protein; c-Kirsten-ras protein; c-Kirsten-ras proto-oncogene; c-ras-Ki-2 protein; cellular c-Ki-ras2; cellular c-Ki-ras2 proto-oncogene; cellular transforming proto-oncogene; GTP- and GDP-binding peptide B; GTPase Hras1; H-ras 1 protein; H-Ras-1; Ha-Ras1 proto-oncoprotein; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; Harvey rat sarcoma virus oncogene; Harvey rat sarcoma virus oncogene 1; HRAS; K RAS; K-Ras 2; K-ras p21 protein; ki-Ras; Kirsten rat sarcoma oncogene 2, expressed; Kirsten rat sarcoma viral oncogene homolog; Kirsten rat sarcoma viral oncogene homologue 2 (active); Kirsten rat sarcoma viral proto-oncogene; KRAS-ENOPH fusion; Kras-Enoph1 fusion protein; N-ras protein part 4; Neuroblastoma RAS; neuroblastoma ras oncogene; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; Nras; oncogene KRAS2; p19 H-RasIDX protein; p21 protein; p21ras; PR310 c-K-ras oncogene; PR371 c-K-ras oncogene; proto-oncogene GTPase; Ras family small GTP binding protein H-Ras; RASK; RASN; small GTP binding protein; transformation gene: oncogene HAMSV; transforming protein N-Ras; transforming protein P21; unnamed protein product; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; v-ras neuroblastoma RAS viral oncogene homolog

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Gene Aliases: 'C-K-RAS; ALPS4; C-BAS/HAS; C-H-RAS; c-Ha-ras; C-HA-RAS1; C-K-RAS; c-Ki-ras; c-Ki-ras2; c-rasHa; CFC2; CMNS; CTLO; H-RAS; H-RASIDX; Ha-ras; HAMSV; Harvey-ras; HRAS; Hras-1; HRAS1; K-Ras; K-Ras 2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KI-RAS; Kras-2; KRAS1; KRAS2; N-ras; NCMS; NRAS1; NS; NS3; NS6; OES; p21; p21B; p21ras; RALD; RALD1; RALD2; ras; RASH1; RASK2

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UniProt ID: (Human) P01112, (Mouse) Q61411, (Rat) P20171, (Human) P01116, (Mouse) P32883, (Rat) P08644, (Pig) Q2MJK3, (Human) P01111, (Rat) Q04970

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Entrez Gene ID: (Human) 3265, (Pig) 110259208, (Mouse) 15461, (Rat) 293621, (Pig) 100518251, (Human) 3845, (Mouse) 16653, (Rat) 24525, (Pig) 100739349, (Human) 4893, (Mouse) 18176, (Rat) 24605

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Function(s)
GTPase activity obsolete small monomeric GTPase activity protein binding GTP binding GDP binding protein anchor phospholipase C activator activity macromolecular complex binding GMP binding LRR domain binding identical protein binding small GTPase
Process(es)
MAPK cascade regulation of transcription from RNA polymerase II promoter chemotaxis signal transduction cell surface receptor signaling pathway Ras protein signal transduction positive regulation of cell proliferation negative regulation of cell proliferation insulin receptor signaling pathway organ morphogenesis negative regulation of gene expression Schwann cell development positive regulation of cell migration regulation of actin cytoskeleton organization regulation of cell proliferation myelination positive regulation of MAPK cascade positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade positive regulation of Ras protein signal transduction positive regulation of epithelial cell proliferation regulation of cell cycle adipose tissue development positive regulation of ERK1 and ERK2 cascade cellular response to gamma radiation positive regulation of wound healing positive regulation of protein targeting to membrane cellular senescence regulation of neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of ruffle assembly positive regulation of miRNA metabolic process endocytosis small GTPase mediated signal transduction positive regulation of gene expression positive regulation of interferon-gamma production ERBB2-ERBB3 signaling pathway T-helper 1 type immune response defense response to protozoan negative regulation of neuron apoptotic process insulin-like growth factor receptor signaling pathway regulation of long-term neuronal synaptic plasticity T cell receptor signaling pathway oncogene-induced cell senescence intrinsic apoptotic signaling pathway liver development response to isolation stress positive regulation of DNA replication I-kappaB kinase/NF-kappaB signaling female pregnancy response to gravity cytokine-mediated signaling pathway positive regulation of TOR signaling negative regulation of programmed cell death response to glucocorticoid response to mineralocorticoid myoblast proliferation cardiac muscle cell proliferation positive regulation of cellular senescence visual learning gene expression forebrain astrocyte development actin cytoskeleton organization regulation of synaptic transmission, GABAergic positive regulation of Rac protein signal transduction positive regulation of MAP kinase activity negative regulation of cell differentiation homeostasis of number of cells within a tissue positive regulation of nitric-oxide synthase activity striated muscle cell differentiation epithelial tube branching involved in lung morphogenesis positive regulation of endothelial cell proliferation regulation of protein phosphorylation regulation of gene expression positive regulation of angiogenesis positive regulation of fibroblast proliferation negative regulation of skeletal muscle tissue development myoblast differentiation
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