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Invitrogen
pro-GDF1 Polyclonal Antibody
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Product Details
PA5-148664
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse GDF-1 Propeptide, Pro25-Leu235
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Pro-GDF1, or pro-growth differentiation factor 1, is the precursor form of GDF1, a protein that belongs to the transforming growth factor-beta (TGF-beta) superfamily. GDF1 is involved in various developmental processes, particularly in embryogenesis and the development of the central nervous system and cardiovascular system. During its synthesis, pro-GDF1 undergoes proteolytic processing to become the mature, active form. GDF1 plays a crucial role in the formation of the left-right axis during embryonic development, which is essential for the proper positioning and orientation of internal organs. It is also implicated in the regulation of cell differentiation and growth. Mutations or dysregulation in the GDF1 gene can lead to congenital heart defects, heterotaxy (a condition where the internal organs are abnormally arranged), and other developmental anomalies. Understanding the function and regulation of pro-GDF1 and its mature form is important for elucidating the molecular mechanisms underlying normal development and congenital disorders. Research into pro-GDF1 provides insights into the broader roles of TGF-beta family proteins in growth and differentiation, with potential implications for therapeutic strategies aimed at correcting developmental defects and promoting tissue regeneration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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