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Fabgennix
proBNP Polyclonal Antibody
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Product Details
PBNP-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within aino acid region 100-150 on human proBNP protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
In cardiac tissue brain natriuretic peptide (BNP) is synthesized as 134 amino acid precursor (prepro-BNP), which is cleaved by proteases to form a 26 aa "signal" peptide and a 108 aa pro-BNP. Proteolytic digestion of pro-BNP results in formation of 76 aa amino-terminal NT-proBNP and biologically active 32 aa BNP hormone molecule. Both proBNP and NTproBNP circulate in human plasma and have been proposed as markers for early diagnosis of left ventricular dysfunction as well as prognostic markers of possible cardiac complications at patients with heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BNP32; Brain natriuretic factor; brain natriuretic factor prohormone; brain natriuretic peptide; brain type natriuretic peptide; gamma-brain natriuretic peptide; iso-ANP; natriuretic peptide precursor B; natriuretic peptide precursor type B; natriuretic protein; NPPB; NTproBNP; preproBNP; pro-BNP; proBNP; type-B natriuretic factor; unnamed protein product
Gene Aliases: BNF; BNP; Iso-ANP
UniProt ID: (Human) P16860, (Mouse) P40753, (Rat) P13205
Entrez Gene ID: (Human) 4879, (Mouse) 18158, (Rat) 25105
system process
negative regulation of systemic arterial blood pressure
cardiac conduction system development
cGMP biosynthetic process
protein folding
cell surface receptor signaling pathway
receptor guanylyl cyclase signaling pathway
neuropeptide signaling pathway
body fluid secretion
regulation of blood pressure
negative regulation of angiogenesis
negative regulation of cell growth
killing of cells of other organism
positive regulation of urine volume
positive regulation of renal sodium excretion
regulation of vascular permeability
antimicrobial humoral immune response mediated by antimicrobial peptide
regulation of blood vessel diameter
MAPK cascade
endothelial cell proliferation
cardiac muscle hypertrophy in response to stress
response to nutrient levels
cGMP metabolic process
negative regulation of smooth muscle cell proliferation
homeostasis of number of cells
coronary vasculature development
response to oxygen levels
positive regulation of collecting lymphatic vessel constriction
negative regulation of cholangiocyte proliferation
response to hypoxia
heart development
response to nutrient
response to xenobiotic stimulus
response to lipopolysaccharide
response to peptide hormone
response to calcium ion
cell growth involved in cardiac muscle cell development
cellular response to mechanical stimulus
response to 3-methylcholanthrene
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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