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Proteintech
uPAR Polyclonal Antibody
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Product Details
10286-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
uPAR Fusion Protein Ag0187 (1-136 aa encoded by BC002788)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGHPPLLPL LLLLHTCVPA SWGLRCMQCK TNGDCRVEEC ALGQDLCRTT IVRLWEEGEE LELVEKSCTH SEKTNRTLSY RTGLKITSLT EVVCGLDLCN QGNSGRAVTY SRSRYLECIS CGSSDMSCER GRHQSLQ (1-136 aa encoded by BC002788)
Target Information
The urokinase-type plasminogen activator receptor is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in many normal as well as pathologic processes. The human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein of about 50 kD in monocytes where it is anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. PLAUR, also known as UPAR, is directly associated with the carbohydrate-binding domain of SELL in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins. PLAUR-mediated calcium mobilization is SELL dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas and show a 33-fold increase in UPAR mRNA levels in advanced clinical stage endometrial tumors compared with normal endometrial tissue. Furthermore, the increase in UPAR mRNA levels correlated linearly with the progression of disease stage. UPAR protein expressioin correlated positively with rate of recurrence and mortality in patients with endometrial cancer. UPAR appears to be a useful prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD87; Monocyte activation antigen Mo3; sCD87; soluble CD87; U-PAR; u-plasminogen activator receptor form 2; urokinase plasminogen activator receptor; Urokinase plasminogen activator surface receptor; urokinase-type plasminogen activator (uPA) receptor; urokinase-type plasminogen activator receptor
Gene Aliases: CD87; MO3; PLAUR; U-PAR; UPAR; URKR
UniProt ID: (Human) Q03405, (Mouse) P35456
Entrez Gene ID: (Human) 5329, (Mouse) 18793
positive regulation of protein phosphorylation
movement of cell or subcellular component
chemotaxis
signal transduction
blood coagulation
attachment of GPI anchor to protein
regulation of proteolysis
urokinase plasminogen activator signaling pathway
fibrinolysis
negative regulation of apoptotic process
positive regulation of DNA binding
positive regulation of epidermal growth factor receptor signaling pathway
positive regulation of release of cytochrome c from mitochondria
negative regulation of intrinsic apoptotic signaling pathway
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
positive regulation of gene expression
mesenchymal cell differentiation
epithelial cell differentiation involved in prostate gland development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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