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uPAR Polyclonal Antibody
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FIGURE: 1 / 2
uPAR Antibody (PA5-70606) in ICC/IF
PloS one 2022 -
10.1371/journal.pone.0273811.g005 Fig 5 Immunofluorescence images of uPA and uPAR expression in osteosarcoma cell lines. Both diffuse cytoplasmic and nuclear uPA and uPAR positivity are seen in one human osteosarcoma cell line (A) and two canine cell lines D17 (B) and Dharma (C). Nuclear expression was strong in uPA and weak to moderate in uPAR in all three cell lines. Nuclei were stained with DAPI (blue). ... View More
Product Details
PA5-70606
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the N-terminal region of uPAR
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Human: 100%; Mouse: 82%
Target Information
The urokinase-type plasminogen activator receptor is a key molecule in the regulation of cell-surface plasminogen activation and plays an important role in many normal as well as pathologic processes. The human PLAUR cDNA encodes 335 amino acids including a predicted signal peptide of 22 residues and a hydrophobic C-terminal portion. It produces a highly glycosylated protein of about 50 kD in monocytes where it is anchored to the plasma membrane by glycosyl-phosphatidylinositol linkage. PLAUR, also known as UPAR, is directly associated with the carbohydrate-binding domain of SELL in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins. PLAUR-mediated calcium mobilization is SELL dependent. UPAR mRNA levels correlate with the invasive potential of endometrial carcinomas and show a 33-fold increase in UPAR mRNA levels in advanced clinical stage endometrial tumors compared with normal endometrial tissue. Furthermore, the increase in UPAR mRNA levels correlated linearly with the progression of disease stage. UPAR protein expressioin correlated positively with rate of recurrence and mortality in patients with endometrial cancer. UPAR appears to be a useful prognostic marker for advanced endometrial cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD87; Monocyte activation antigen Mo3; PLAUR; sCD87; soluble CD87; suPAR; u-PA receptor; U-PAR; u-plasminogen activator receptor form 2; unnamed protein product; Urokinase plasminogen activator surface receptor; urokinase-type plasminogen activator (uPA) receptor
Gene Aliases: CD87; MO3; PLAUR; U-PAR; UPAR; URKR
UniProt ID: (Human) Q03405
Entrez Gene ID: (Human) 5329
positive regulation of protein phosphorylation
chemotaxis
signal transduction
blood coagulation
regulation of plasminogen activation
regulation of cell adhesion
regulation of proteolysis
positive regulation of homotypic cell-cell adhesion
urokinase plasminogen activator signaling pathway
negative regulation of apoptotic process
positive regulation of DNA binding
positive regulation of epidermal growth factor receptor signaling pathway
regulation of fibrinolysis
positive regulation of release of cytochrome c from mitochondria
negative regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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