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Predicted to react with Mouse and Rat samples.
A-Myb is expressed at specific times in reproductive tissues, some neural cells, and a subset of normal and neoplastic B lymphocytes. Both A-Myb and B-Myb are expressed in t(14:18) lymphoma cells where they then inhibit cell arrest and apoptotic signaling. Expression of B-Myb rescues cells from p53-induced G1 phase arrest that is mediated by p21, while A-Myb functions as an anti-apoptotic factor by effectively activating the bcl-2 promoter and thereby up-regulating Bcl-2 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: A-Myb; Myb-like protein 1; Myb-related protein A; MYBA; v-myb avian myeloblastosis viral oncogene homolog-like 1; VMYB
Gene Aliases: A-MYB; AMYB; G1-419-6; MYBL1; repro9
UniProt ID: (Human) P10243, (Mouse) P51960
Entrez Gene ID: (Human) 4603, (Rat) 297783, (Mouse) 17864
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