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xCT Polyclonal Antibody
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FIGURE: 1 / 4
xCT Antibody (600-401-GU3) in ICC/IF
Immunofluorescence Microscopy of Rabbit anti-xCT antibody. Tissue: PC3 cells. Fixation: 100% MeOH. Antigen retrieval: not required. Primary antibody: xCT antibody at 10 µg/mL overnight at 4°C. Secondary antibody: Donkey Anti-Rabbit IgG DyLight™ 488 (p/n 611-741-127) at 5 µg/mL for 2 h at RT. Localization: xCT is localized on the cell membrane and vesicles. Staining: xCT as green fluorescent signal with DAPI (blue) nuclear counterstain.
Product Details
600-401-GU3
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-xCT antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal portion of human xCT conjugated to Keyhole Limpet Hemocyanin (KLH).
Conjugate
Form
Liquid
Concentration
1.02 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This affinity purified antibody is directed against human xCT. Blast analysis of the sequence of the immunogen shows 100% identity with human and orangutan, and 88% identity to mouse.
Target Information
SLC7A11 (also known as XCT) is a member of a hetromeric, sodium-independent, anionic amino acid transport system. It is highly specific for cysteine and glutamate. SLC7A11 is a mediator of Kaposi sarcoma-associated herpes virus fusion and entry into cells. Increased expression of this protein in primary gliomas is associated with neuronal cell death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Amino acid transport system xc-; Calcium channel blocker resistance protein CCBR1; Cystine/glutamate transporter; solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11; Solute carrier family 7 member 11; solute carrier family 7, (cationic amino acid transporter, y+ system) member 11; unnamed protein product; X-c transporter; xCT
Gene Aliases: CCBR1; SLC7A11; xCT
UniProt ID: (Human) Q9UPY5
Entrez Gene ID: (Human) 23657
amino acid transmembrane transport
glutathione metabolic process
amino acid transport
brain development
visual learning
response to toxic substance
L-cystine transport
L-glutamate transport
ventricular system development
striatum development
adult behavior
regulation of neutrophil apoptotic process
cellular response to stress
cellular response to oxidative stress
glutathione transmembrane transport
regulation of cell proliferation
regulation of programmed cell death
regulation of melanin biosynthetic process
lung alveolus development
modulation of synaptic transmission
regulation of synapse organization
regulation of protein transport
response to redox state
transmembrane transport
limb development
platelet aggregation
glutamate homeostasis
L-glutamate import across plasma membrane
negative regulation of ferroptosis
dipeptide import across plasma membrane
L-kynurenine transmembrane transport
regulation of cellular response to oxidative stress
regulation of cysteine metabolic process
regulation of glutathione biosynthetic process
regulation of AMPA glutamate receptor clustering
regulation of glutamate metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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