Chromatin immunoprecipitation (ChIP) experiments examine histone modifications and genomic DNA sequences bound to specific regulatory proteins. In ChIP, protein-DNA complexes are crosslinked in vivo, immunoprecipitated, purified, and amplified for gene- and promoter-specific analysis of known targets or for the identification of new target sequences. In a related microarray-based method, ChIP-on-Chip, the immunoprecipitated DNA is labeled and hybridized to high-resolution microarrays.
Chromatin Biology
Chromatin Immunoprecipitation
We offer a variety of products for chromatin immunoprecipitation, including protein A and G reagents, antibodies, and PCR and qPCR reagents.
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ChIP-on-Chip
We offer a number of products for the ChIP-on-Chip workflow, including reagents for immunoprecipitation, PCR, and microarray labeling and hybridization.
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Chromatin-Related Products
| Reagents for detection of chromatin, histones, and methyltransferases, as well as DNA fragmentation and chromatin condensation. |
Epigenetics Learning Center
Our Learning Center provides an overview of epigenetic regulation of gene expression as well as considerations underpinning the research workflow. Learn about:
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Literature
Chromatin Research Topics
- Overview of chromatin
- Histone modifications and histone variants
- Chromatin remodeling and gene regulation
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Questions
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