Discover. Innovate. Exceed. — Introducing the Thermo Scientific Orbitrap Excedion Pro Mass Spectrometer

Mass spectrometry is entering a new era of precision, performance, and productivity.

The Thermo Scientific Orbitrap Excedion Pro mass spectrometer brings together decades of Orbitrap innovation with the latest engineering advances, giving researchers the freedom to explore complex molecules with unmatched clarity and confidence.

Next-generation hybrid design

At the heart of the Excedion Pro lies a high-field Orbitrap analyzer, advanced ion optics, and Thermo Fisher’s most sophisticated quadrupole and ion routing architecture to date.

Key engineering highlights:

Ultra high-field Orbitrap analyzer — delivers up to 70 Hz MS² scan rates and an extended mass range to m/z 12 000, enabling intact and native analyses from small molecules to large proteins.
Advanced Quadrupole Technology (AQT) — achieves ultra-precise precursor isolation for cleaner spectra and confident quantitation.
OptaMax Plus ion source — provides enhanced spray stability, minimal maintenance, and reproducible ionization across workflows.
Electrodynamic ion funnel — boosts transmission efficiency, especially for labile or low-abundance species.
Ion-routing multipole — allows HCD, ETD, and EThcD fragmentation within a single module, supporting all fragmentation strategies without hardware changes.

Figure 1: 2D layout diagram showing the key engineering components of the Orbitrap Excedion Pro Mass Spectrometer

Designed for the modern researcher

From discovery proteomics to structural biopharma characterization, the Excedion Pro is optimized to deliver deeper insights faster.

Researchers can expect:

Higher sensitivity and dynamic range with eDR scan mode — detect low-level peptides and modifications with ease.
Broader sequence coverage through EASY-ETD/EThcD fragmentation — preserve fragile PTMs while achieving full peptide mapping.
Quantitative confidence using the Hybrid-DIA workflow — combining data-independent and data-dependent acquisition for precise results with fewer false positives.
Versatility across mass ranges — analyze everything from small molecules to intact complexes on one platform.

Applications that benefit most

Research area	What Excedion Pro MS enables
Proteomics	Fast, deep coverage with hybrid fragmentation; improved quantitation for DIA/DDA workflows
Biopharma	Precise ADC conjugation mapping, PTM localization, and DAR determination
Structural Biology	High-sensitivity HDX-MS and native MS to probe protein folding and dynamics
Metabolomics & Lipidomics	Extended dynamic range for low-abundance analytes with confident compound ID

Built for confidence and sustainability

Performance meets practicality.

A single-dry-pump design reduces power consumption by ~30%, lowers noise and heat output, and streamlines maintenance — aligning advanced analytical capability with sustainable operation.

Answering key questions

Q: What makes the Orbitrap Excedion Pro different from previous Orbitrap instruments?

A: It combines a next-generation high-field Orbitrap analyzer, new ion routing multipole, and enhanced dynamic range (eDR) to deliver both speed and precision across a wider mass range.

Q: Which applications benefit from EASY-ETD and HCD fragmentation?

A: Proteomics, PTM analysis, and ADC characterization all gain improved coverage and modification localization using these complementary modes.

Q: Is the Excedion Pro suitable for both discovery and QC environments?

A: Yes — its stability, throughput, and intuitive software workflows make it equally powerful for research discovery, translational studies, and regulated analytical environments.

The Future of Hybrid Mass Spectrometry

The Orbitrap Excedion Pro mass spectrometer embodies Thermo Fisher’s commitment to scientific innovation — combining resolution, sensitivity, and flexibility into one intelligent platform. Whether you’re discovering new biomarkers, monitoring therapeutic quality, or exploring molecular structure at atomic detail, the Excedion Pro helps you see more, know more, and do more.

Learn more about Orbitrap Excedion Pro Mass Spectrometers

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