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Elevate Your HPLC Performance with a Modern CDS

By 10.24.2025

You may have the best HPLC system on the market, but to maximize your investment, you also need the best software to control the system and manage the data. If the software is complex to use, inflexible or lacking in functionality, it can greatly reduce your lab productivity, creating bottlenecks and inefficiencies. Furthermore, this can lead to unreliable results, increased error rates, cost implications and ultimately, a decrease in overall laboratory performance. By selecting the right Chromatography Data System (CDS) designed to meet current laboratory needs, you can eliminate errors and drive productivity with data that is accurate, trustworthy and secure.

Elevate Your HPLC Performance with a Modern CDS

Be flexible and be in control

So, what if you have multiple HPLC’s from different vendors? Thermo Scientific Chromeleon CDS offers full control over the widest range of HPLC and other chromatography instruments, including those from third-party manufacturers. This ensures you can maintain flexibility, while connecting and controlling your HPLC systems effortlessly. With features, such as auto-generated instrument panels that provide fast access to commands and live analysis plots, you can simplify navigation and enhance the overall user experience, making it easier to manage and monitor instruments.

Streamline your method development and validation

Support for your method development and validation needs is taken care of with predefined ICH method validation templates and built-in tools for method conversion, alongside integration with specialized software for automated and intelligent HPLC method development. This integration facilitates faster and more efficient method optimization and robustness testing, while the secure centralized data storage builds the perfect platform for compliance and future data review, providing a complete solution from method development to validation.

Robust compliance and secure data management

Compliance and security can be a crucial aspect of any HPLC operation, and Chromeleon CDS effectively addresses these needs. Your instrument management starts with fast integrated wizard-driven instrument qualification covering IQ, OQ and PQ with predefined templates and reports to optimize the instrument qualification process. The software employs a privilege-based approach to control access to both the instruments and the system, ensuring that only authorized and qualified personnel can interact with them. Dedicated instrument audit trails track all actions and will provide you with a full history that is searchable ensuring traceability, safeguarding the integrity of your data and operations.

Keep your instruments up and running

Productivity is only maintained if your HPLCs are operational and available for use. Integrated diagnostic tests offer insight into key information such as lamp operating hours or piston seal wear with warning limits for timely replacements. The active monitoring of service and qualification status allows for convenient maintenance scheduling and prevents unnecessary instrument downtime. An overview of diagnostic outcomes can also be produced as part of a routine health check ensuring that your HPLC instruments are always in optimal condition.

Get more right-first-time results

How can you prevent delays, time-consuming investigations, and ensure your analytical sequence runs correctly the first time? Chromeleon CDS offers you solutions to minimize user interaction, such as ready checks that automatically verify instrument configuration, methods, and sequences for issues, and automated system equilibration, which ensures the first injection is always good, eliminating the need for blank injections at the start of a sequence saving time and solvent. Automated shutdown procedures will manage a completed run, ensuring safe shutdown, system flushing, or maintaining a low flow rate to prevent component damage. Built-in system suitability tests with the ability to make in-run decisions, such as pause, stop or continue will maintain the integrity of your data and allow you to perform actions like re-injections and auto-dilutions for when samples are outside acceptable tolerance limits. Streamlining and automating the entire process of sequence creation is achieved through eWorkflow procedures. These pre-defined templates contain all associated methods and reports, so your HPLC sequence can be automatically generated with just a few clicks, reducing errors, minimizing training, and producing reliable results faster.

A software designed to optimize HPLC lab efficiency

Chromeleon CDS is a no-compromise solution for your HPLC systems, designed to provide you with faster and better results through enhanced control, flexibility, diagnostics, right-first-time results, and compliance. Its user-friendly interface, comprehensive method development and validation tools, secure data management, and advanced diagnostics make it an indispensable tool for your HPLC laboratory. Find out more by downloading the case study: Leveraging a Vanquish UHPLC system and Chromeleon CDS to optimize the manufacturing process or visiting Chromatography Data System (CDS).

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Peter Zipfell

For over 25 years, he has worked extensively with analytical hardware and software transitioning from LC-MS method development through HPLC technical support to chromatography data systems. His focus has always been to support our customers by delivering software solutions across multiple industries to enable them to improve their current workflows and increase productivity.