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Accelerating ScienceBehind the Bench / Forensics / Next-Generation Sequencing for Forensic DNA Analysis

Next-Generation Sequencing for Forensic DNA Analysis

Written by Angie Lackey | Published: 09.19.2016

Human identification in forensics using DNA has traditionally been accomplished by analyzing a series of short tandem repeat (STR) markers using capillary electrophoresis. But there are times when STR analysis can’t provide an answer- when samples are low in quantity, are degraded, or there was no STR match in the DNA database. Enter Single Nucleotide Polymorphisms (SNPs) as alternative markers to generate additional investigative lead information from casework samples. As next-generation sequencing, and the ability to multiplex many markers for a single sample, has gained acceptance within the forensic community, so has SNP genotyping. There are a number of SNP classifications that are currently being investigated; including identity SNPS, phenotypic SNPs and biogeographic ancestry SNPs. Since 2014, France has allowed the use of phenotypic SNP analysis on crime scene samples to aid in criminal investigations, but only when an STR profile does not get a match in a database. Institute Genetics Nantes Atlantique (IGNA) is a pioneer in forensic DNA analysis and today they are largest private forensic lab in France, offering DNA typing using STRs, mtDNA analysis as well as SNP genotyping. Executive Director Soizic Le-Gunier discusses how IGNA uses the various technology options and how SNP genotyping will have an impact in the future.

For Research, Forensic or Paternity Use Only. Not for use in diagnostic procedures. 

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