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Automate and streamline magnetic separation
Manual magnetic separation steps can be time-consuming and difficult to standardize across operators and scales. The Gibco CTS DynaCellect Magnetic Separation System is designed to automate these tasks within a closed, benchtop system that supports consistent operation, helps reduce manual touchpoints, and facilitates reproducibility across T cell therapy workflows.
Features of CTS DynaCellect Magnetic Separation System
The CTS DynaCellect Magnetic Separation System supports efficient magnetic bead-based cell handling with processing speed, flexibility, and scalability suited for T cell therapy manufacturing. Its connected design—used with the Gibco CTS DynaCellect Cell Isolation Kit, Gibco CTS DynaCellect Bead Removal Kit, and programmable software—helps standardize steps while supporting reproducible performance across cell therapy processes.
Explore the CTS DynaCellect Magnetic Separation System 3D interactive tour
Interact with a detailed view of the system to see how its components, user interface, and process flow work together in a closed, automated format.
Empower control with the clinical manufacturing mode
Strengthen process control during scale-up by using the clinical manufacturing mode available for the CTS DynaCellect Magnetic Separation System. This mode locks optimized protocols to support consistent operation, and an optional software module supports 21 CFR Part 11-aligned record-keeping with configurable user roles, audit logging, and e-Signature workflows managed through the SAE Administrator Console. A licensed installation is completed by a field service engineer (FSE).
Table 1. Functionality of the SAE Administrator Console
Function |
Description |
System security |
Controls user access to the software through user IDs, passwords, roles, and permissions. Three default user roles are offered: one with full privileges (Administrator), one with some privileges (Lead Scientist), and the other with no privileges (Technologist). Default user roles can be edited, and additional user roles and permissions can be created. |
Auditing |
Tracks actions performed by users and changes to the SAE Admin Console settings. The software silently audits some actions. You can select other items for auditing and specify the audit mode. The auditing function allows reports for audited SAE Admin Console changes and actions. |
| Electronic signature (e-Signature) |
Determines the functions for which users are required to give a username and password. You can configure e-Signatures, so a user can export a signed file and print a signed report. You can also configure the e-Signature event to require multiple signatures and to require users with specific permissions to sign. |
Evaluate performance in T cell isolation and activation
The CTS DynaCellect Magnetic Separation System helps users easily scale from research to clinical and commercial manufacturing. This highly scalable system uses a continuous flow process for bead removal, allowing for easy scaling, verified from 50 mL to 10 L of reaction volume (with optimal total target cell range of 108 to 1010) for cell isolation.
- High purity
- Isolation efficiency and cell viability
- Activation
Assess enrichment outcomes using the CTS DynaCellect Magnetic Separation System with CTS Dynabeads CD3/CD28 beads.
Figure 1. Cell phenotype of the starting material and enriched target cells after isolation. (A) The proportion of target cells in the unwashed starting material was ~53.6%. (B) After isolation using CTS Detachable Dynabeads CD3/CD28 and the CTS DynaCellect Magnetic Separation System, the purity of the target T cells was ~97.7% as measured by flow cytometry.
Review isolation efficiency and viability performance supported by the magnetic system.
Figure 2. High isolation efficiency with no impact on cell viability. Using CTS Detachable Dynabeads CD3/CD28 and the CTS DynaCellect Magnetic Separation System, (A) the average isolation efficiency was 92.8% (n = 4), and (B) the viability of isolated cells was slightly increased across bead release days 1 through 3, as determined by flow cytometry.
Track activation marker expression following isolation with the system.
Figure 3. Confirmed activation of isolated target cells. CTS Detachable Dynabeads CD3/CD28 were released on days 1, 2, and 3 after isolation. The early activation marker CD69 was expressed on target cells on day 1 and was downregulated by day 3. The late activation marker CD25 was highly expressed on day 1 and continued to be upregulated through day 3. The expression profile adheres to expected target cell kinetics (n = 4).
System specifications
Support consistent operation across development and manufacturing with the CTS DynaCellect Magnetic Separation System, produced in a GMP and ISO-certified facility. The system can function as a standalone instrument or integrate into closed cell therapy workflows, with scalable operation that spans small development volumes through larger clinical and commercial needs.
Table 2. Instrument specifications
Processing time |
~70–100 minutes |
Efficiency |
>88% isolation (with CTS Detachable Dynabeads CD3/CD28) |
Yes |
|
Reproducibility |
Coefficient of variation (CV) of 3% |
Purity |
97% (with CTS Detachable Dynabeads CD3/CD28) |
Viability |
Unaffected |
Isolation scale |
Maximum 1,000 mL working volume (equivalent to ~1010 T cells as input) |
Bead removal scale |
Verified up to 10 L |
Maximum cell input |
~1010 T cells (1,000 mL isolation volume) |
Pump speed |
1–150 mL/min |
Rocker angle |
-30° to 30° |
Rocker speed |
1–30 cpm (cycles per minute) |
Maximum air pressure |
2 bar |
Supports compliance with 21 CFR Part 11 |
Yes, with upgrade |
Open Platform Communications–Unified Architecture (OPC-UA) compatible |
Yes |
Cloud connect utility |
Yes |
Touch display |
20.32 cm |
Voltage |
100–240 V AC ±10%, 50/60 Hz, 600 W |
Weight |
50 kg |
Depth |
562 mm |
Width |
749.5 mm |
Height |
485 mm with pole |
Advance T cell therapies with accessories and consumables
Extend the capabilities of the CTS DynaCellect Magnetic Separation System with single-use consumables for isolation, depletion, and bead removal in your workflows.
Enhance cell therapy workflows with modular solutions
Integrate the CTS DynaCellect Magnetic Separation System with other cell therapy products to support T cell processing.
Software
Configure magnetic separation steps using the system’s user-programmable software, which allows you to create custom protocols with the Protocol Builder. The instrument also offers two standard protocols, one for cell isolation and one for bead removal. Users can adjust magnet engagement, pump speed, rocker settings, and valve positions to meet process needs. Once optimized, protocols can be locked in clinical manufacturing mode, with optional features that support 21 CFR Part 11-aligned record-keeping, audit logging, user-level permissions, and summary file generation.
System services
Maintain reliable CTS DynaCellect Magnetic Separation System operation with global service coverage, warranty options, and qualification support to help keep your instrument performing as expected throughout its lifecycle. More than 2,000 trained professionals make up our service and support network, ready to assist you when you need it. Each system comes with a standard 1-year warranty, which covers costs for travel or shipping, labor, and parts for repairs.
AB Assurance Plan
Extend support with the AB Assurance Plan, which adds a year of coverage and includes scheduled maintenance, remote diagnostics, and prioritized access to trained service engineers. The plan includes parts, labor, travel, and software updates to maintain instrument operation.
Table 3. AB Assurance Plan overview
Service aspect |
AB Assurance Plan |
Response time |
2 business days* |
✓ |
|
Parts, labor, and travel |
✓ |
✓ |
|
Available as an add-on |
|
Field application scientist (FAS) consultation |
Available as an add-on |
Technical support (Mon-Fri, standard business hours) |
✓ |
*Response times vary by region
Planned maintenance
Receive a planned maintenance service visit from the FSE as part of the AB Assurance Plan during the second year. During this visit, the engineer inspects the system, performs software updates as needed, cleans and lubricates components, completes calibration and functional testing, and documents findings to help you prevent downtime, reduce strain on your staff, and help extend the life of your instrument.
Purchasing service plans
Select a service plan at the time of your purchase or add an extended warranty later, depending on regional availability. Customers may contact their sales representative for guidance on options that allow additional coverage or extend support for their CTS DynaCellect Magnetic Separation System.
Qualification services
Add instrument hardware qualifications, such as Installation Qualification (IQ) and Operational Qualification (OQ), to document system installation and verify that subsystems operate within manufacturer specifications. These services are recommended during installation, after major maintenance, following an instrument move, or after software or hardware updates, with audit-ready documentation by qualification specialists.
AB Qualification Service
Access an additional on-site OQ visit within two years of installation to assess system performance after major maintenance or changes. The FSE conducts testing that challenges operating parameters and documents the results, supporting traceability and regulatory expectations for cell therapy manufacturing environments.
Related resources
Frequently asked questions
The CTS DynaCellect Magnetic Separation System is designed to automate bead-based magnetic separation steps for T cell isolation and activation. It supports cell isolation and bead removal in a closed, automated format, helping maintain process consistency and operator efficiency. The system is designed for use with both CTS Dynabeads magnetic beads and CTS Detachable Dynabeads magnetic beads to support controlled magnetic separation across manufacturing stages.
The CTS DynaCellect Magnetic Separation System supports both autologous and allogeneic T cell therapy workflows through its scalable isolation volumes and continuous-flow bead process. Users can adapt protocols to different starting materials and batch sizes, enabling instrument use for both small autologous runs to larger manufacturing formats used in allogeneic processes.
The CTS DynaCellect Magnetic Separation System is designed for use in closed, automated workflows that support GMP-aligned bioprocessing. Its single-use consumables, weldable tubing, and programmable software help maintain process control, reduce manual handling, and support electronic record-keeping when used with the optional 21 CFR Part 11 software module.
Additional bioprocessing resources
Bioprocessing resources
For Research Use Only. Not for use in diagnostic procedures.