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Invitrogen
Human Complement C5b-9 (soluble) ELISA Kit
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Product Specifications
Analytical sensitivity
18.75 ng/mL
Assay range
31.25-2,000
Sample type/volume
Plasma
100 µL
Serum
100 µL
Hands-on time
1 hr 20 min
Time-to-result
2 hr 30 min
Homogenous (no wash)
No
Interassay CV
<10%
Intraassay CV
<10%
Instrument
Absorbance Microplate Reader
Product size
96 Tests
Contents
Pre-coated microwell plate
Standard
Biotinylated Detection Antibody
Streptavidin-HRP
Standard and Sample Diluent
Biotinylated Detection Antibody Diluent
HRP Conjugate Diluent
Wash Buffer Concentrate
Stop Solution
Substrate Solutio
Adhesive Plate Covers
Standard
Biotinylated Detection Antibody
Streptavidin-HRP
Standard and Sample Diluent
Biotinylated Detection Antibody Diluent
HRP Conjugate Diluent
Wash Buffer Concentrate
Stop Solution
Substrate Solutio
Adhesive Plate Covers
Shipping conditions
Wet ice
Storage
At 2-8°C for one year. Protect from light. Do not freeze.
Protein name
Complement C5b-9
Species (tested)
Human
Assay kit format
Sandwich ELISA Kit
Detector antibody conjugate
Biotin
Label or dye
HRP
About This Kit
The Human sC5b-9 (Soluble Terminal Complement Complex C5b-9) ELISA quantitates sC5b-9 in serum, plasma, and other biological fluids.
Target information
The complement system is a fundamental part of innate immunity, consisting of over 45 genes that encode various complement components, regulators, and receptors. The complement C5b-9 complex, also known as the Membrane Attack Complex (MAC), plays a crucial role in the immune defense mechanism. It includes the sequential assembly of proteins C5b, C6, C7, C8, and multiple copies of C9. This complex forms transmembrane channels that puncture the cell membrane of target cells, leading to cell lysis. Specifically, MAC has significant implications in mediating cell death in both pathogenic organisms and cancer cells. The genes involved are clustered across the human genome, mainly organized in three significant loci. The understanding of the C5b-9 complex's function extends beyond its antimicrobial roles to include its interactions with tumor cells, where it can induce cell death and influence cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Gene aliases : ARMD15, C5, C5a, C5b, C5D, C6, C7, C9, C9D, CPAMD4, ECLZB
Gene ID : (Human) 727, (Human) 729, (Human) 730, (Human) 735
Gene symbol : C5, C6, C7, C9
Protein Aliases : anaphylatoxin C5a analog, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, C5a anaphylatoxin, C5b-9, MAC Complex, Membrane Attack Complex, Complement C5, Complement component C6, Complement component C7, Complement component C9, prepro-C5
UniProt ID (Human) P01031, (Human) P13671, (Human) P10643, (Human) P02748
Performance Guarantee
If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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