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Search Thermo Fisher Scientific
Human FCGR3A/CD16A quantitates human FCGR3A/CD16A in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human FCGR3A/CD16A.
CD16 encodes a receptor that recognizes the Fc portion of immunoglobulin G and is involved in the clearance of immune complexes from the circulation, as well as other functions such as cellular mediated cytotoxicity and enhancement of virus infections. This gene, FCGR3A, shares a high degree of similarity with another nearby gene, FCGR3B, located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, while FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been associated with immunodeficiency 20 and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Diseases associated with FCGR3A include Immunodeficiency 20 and Herpes Zoster.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Gene aliases : CD16, CD16A, CD16B, FCG3, FCGR3, FCGR3A, FCGR3B, FCGRIII, FCR-10, FCRIII, FCRIIIA, FCRIIIb, IGFR3, IMD20
Gene ID : (Human) 2214, (Human) 2215
Gene symbol : FCGR3A, FCGR3B
Protein Aliases : CD16-I, CD16-II, CD16a, CD16a antigen, CD16b, Fc fragment of IgG low affinity IIIa receptor, Fc fragment of IgG, low affinity III, receptor for (CD16), low affinity IIIa, receptor (CD16a), low affinity IIIb, receptor (CD16b), Fc gamma receptor III-A, Fc gamma receptor IIIa, Fc gamma receptor IIIb, Fc-gamma receptor III-2 (CD 16), Fc-gamma receptor IIIb (CD 16), Fc-gamma receptor IIIb (CD16), Fc-gamma RIII, Fc-gamma RIII-alpha, Fc-gamma RIII-beta, Fc-gamma RIIIa, fc-gamma RIIIb, FcgammaRIIIA, FcR-10, IgG Fc receptor III-1, IgG Fc receptor III-2, IgG Fc receptor III-A, immunoglobulin G Fc receptor III, Low affinity immunoglobulin gamma Fc region receptor III-A, Low affinity immunoglobulin gamma Fc region receptor III-B, neutrophil-specific antigen NA
UniProt ID (Human) P08637, (Human) O75015
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