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Invitrogen
Human Mer (MERTK) ELISA Kit
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Product Specifications
Analytical sensitivity
6.96 pg/mL
Assay range
11.72-750 pg/mL
Sample type/volume
Serum
5 µL
Plasma
5 µL
Cell Lysate
5 µL
Hands-on time
1 hr 20 min
Time-to-result
3 hr 30 min
Homogenous (no wash)
No
Interassay CV
7.4%
Intraassay CV
3.9%
Instrument
Absorbance Microplate Reader
Product size
96 Tests
Contents
Pre-coated 96 well plate
Standard (2 vials)
Assay Buffer concentrate
Biotinylated Detection Antibody
Streptavidin-HRP
Wash Buffer
Substrate Solution
Stop Solution
Adhesive Plate Covers
Standard (2 vials)
Assay Buffer concentrate
Biotinylated Detection Antibody
Streptavidin-HRP
Wash Buffer
Substrate Solution
Stop Solution
Adhesive Plate Covers
Shipping conditions
Wet ice
Storage
2-8°C
Protein name
MERTK
Target sub-specificity
Soluble
Protein family
Cell Signaling
Species (tested)
Human
Assay kit format
Sandwich ELISA Kit
Detector antibody conjugate
Biotin
Label or dye
HRP
About This Kit
The Human Mer ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative detection of human Mer.
Target information
MERTK (cMER) is a tyrosine kinase proto-oncogene and is involved in the retinal pigment epithelium (RPE) phagocytosis pathway, which is implicated in human retinal disease. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Gene aliases : c-Eyk, c-mer, MER, MERTK, RP38, Tyro12
Gene ID : (Human) 10461
Gene symbol : MERTK
Protein Aliases : c-mer proto-oncogene tyrosine kinase, MER receptor tyrosine kinase, MERTK, MER, RP38, c-mer, Tyro12, c-Eyk, MER proto-oncogene, tyrosine kinase, MGC133349, sMER, sMERTK, soluble MER, soluble MERTK, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, STK kinase, Tyrosine-protein kinase Mer
UniProt ID (Human) Q12866
Performance Guarantee
If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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