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Invitrogen
Human TDP43 ELISA Kit
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Product Specifications
Analytical sensitivity
0.19 ng/mL
Assay range
0.31-20
Sample type/volume
Plasma
100 µL
Serum
100 µL
Hands-on time
1 hr 20 min
Time-to-result
2 hr 30 min
Homogenous (no wash)
No
Interassay CV
<10%
Intraassay CV
<10%
Instrument
Absorbance Microplate Reader
Product size
96 Tests
Contents
Pre-coated microwell plate
Standard
Biotinylated Detection Antibody
Streptavidin-HRP
Standard and Sample Diluent
Biotinylated Detection Antibody Diluent
HRP Conjugate Diluent
Wash Buffer Concentrate
Stop Solution
Substrate Solutio
Adhesive Plate Covers
Standard
Biotinylated Detection Antibody
Streptavidin-HRP
Standard and Sample Diluent
Biotinylated Detection Antibody Diluent
HRP Conjugate Diluent
Wash Buffer Concentrate
Stop Solution
Substrate Solutio
Adhesive Plate Covers
Shipping conditions
Wet ice
Storage
At 2-8°C for one year. Protect from light. Do not freeze.
Protein name
TDP-43
Species (tested)
Human
Assay kit format
Sandwich ELISA Kit
Detector antibody conjugate
Biotin
Label or dye
HRP
About This Kit
The Human TDP43 (TAR DNA Binding Protein 43) ELISA quantitates TDP43 in serum, plasma, and other biological fluids.
Target information
TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3"e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Gene aliases : ALS10, TARDBP, TDP-43, TDP43
Gene ID : (Human) 23435
Gene symbol : TARDBP
Protein Aliases : OTTHUMP00000002171, OTTHUMP00000002173, RP4-635E18.2, TAR DNA-binding protein 43, TAR DNA-binding protein-43, TDP-43
UniProt ID (Human) Q13148
Performance Guarantee
If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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