What are some key benefits of single-use bioprocessing equipment over conventional stainless steel?

Significant reduction of contamination risk Faster instrument turnaround times Reduction of water use, cleaning materials and electricity

Single-Use Bioprocessing | Thermo Fisher Scientific

Streamline single-use workflows across bioprocessing

Thermo Fisher Scientific is a global leader in single-use technologies and a trusted partner to biomanufacturers seeking to accelerate speed to market while advancing sustainability. Our portfolio of trusted single-use bioreactors and consumables—including bottles, tubing, and single-use bags featuring trusted film technologies—helps reduce contamination risk, increase flexibility and enable dynamic upstream and downstream processing.

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Solutions that support productivity across workflows

Single-use equipment

Designed and manufactured for easy integration and customization across upstream and downstream bioprocessing workflows, our bioprocessing equipment offers ergonomic, scalable solutions that prioritize quality, flexibility, and efficiency.

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Controllers and automation software

Automation software and reliable controllers allow for data transferability and scalability from research to commercial manufacturing.

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Fluid management

From bioprocess bags, bottles, and carboys to filters and tubing assemblies, secured at connection points with the BioTitan Retention Device, our customizable products are designed to safeguard workflows against leaks, contamination, and supply disruptions.

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Bioprocess bottles and carboys

The Nalgene portfolio is designed with precision and innovation, offering containment and protection for your valuable biopharmaceutical processes.

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Single-use bioreactor systems

Enable superior performance and automation with Single-Use Bioreactor systems (S.U.B.). Our versatile portfolio of S.U.B.s support robust production across scales and have the flexibility to accommodate a variety of cell lines and processing modalities.

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Service and support

Connect with our dedicated team of experienced technical professionals to build scalable, streamlined solutions.

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Explore BioProcess Insights

The Bioprocess Insights Hub by Thermo Fisher Scientific is designed for biomanufacturing professionals, offering educational resources to optimize single-use bioprocessing workflows. It features articles, guides, and case studies on topics such as assembly design, contamination mitigation, and technology transfer. Resources include application notes, brochures, white papers, videos, and webinars, covering areas like process optimization, scalability, quality, and sustainability.

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Environmental sustainability in bioprocessing

Single-use technologies are uniquely enabled to help achieve sustainability goals, as they allow for a lower consumption of key resources, especially around water, electricity, space, steelwork, and cleaning products.

Learn more about the benefits of single-use technology when compared to stainless steel

Design your single-use fluid transfer assembly—faster and with confidence

Our Single-Use Assembly Configurator Tool makes it easy to create custom assemblies tailored to your process or select in-stock, ready-to-ship options to help reduce lead times.

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Frequently asked questions

Single-use bioprocessing prevents direct contact of the biologics with equipment by incorporating disposable components like bags, tubing, and liners. This significantly reduces contamination risk and improves equipment turn-around time.

Single use technologies are commonly used in the production of biologic therapeutics and their components including monoclonal antibodies, antibody drug conjugates (ADCs), proteins, mRNA, gene therapies, cell therapies, and more.

Single-use technologies eliminate variables around equipment cleaning including cleaning solutions, water quality, and operator variability. Many disposable components for single-use systems like those sold through Thermo Scientific are made from the same films creating a consistent product contact layer.

Supply chains and finding the correct single-use components can be challenging. When adopting single-use it is important to select a supplier with a robust, redundant supply chain and support to help ensure that you can get components when you need them. Thermo Fisher’s global manufacturing network helps provide supply assurance to our customers. Another challenge can be leaks. Thermo Fisher has incorporated the Thermo Scientific BioTitan Retention Device, a replacement for cable ties to virtually eliminate leaks from connection points.

Scalability is improved with consistent films like the Aegis 5-15 used across many types of bags, controllers with consistent software, and high turndown ratios. For example, the Thermo Scientific DynaDrive Single-Use Bioreactor 5000 L has a 20:1 turndown ratio, which reduces steps in the feed train. Our equipment and control platforms scale easily from 1 L working volume to 5,000 L.

Single-use technologies eliminate the need for extensive cleaning steps between batches. Cleaning traditional stainless-steel equipment uses significant amounts of water, cleaning solutions and electricity which often has a larger environmental impact than use of disposable components. Learn more about environmental sustainability in bioprocessing.