Bioprocess Resin Selection Guide

Find chromatography resins suited to your workflow

Use our interactive resin selection guide to compare options and review applications. Access resources that support process development and scale-up.

Frequently asked questions

Choosing a chromatography resin depends on factors such as binding capacity, scalability, and fit for your molecule. Our resin selection guide allows side-by-side comparison to help align resin performance with your process goals.

CaptureSelect resins help achieve targeted purification of antibody variants, therapeutic proteins, and viral vectors based on finely tuned affinity ligands. POROS resins feature a small, rigid backbone with tuned pore sizes that facilitate high binding capacity and rapid mass transfer for bioprocessing across therapeutic modalities, including mAbs, mRNA, and gene therapy. Both are used in discovery, clinical development, and commercial manufacturing. Learn more about CaptureSelect and POROS resins.

Key considerations for scale-up include resin binding capacity, column sizing, and facility fit. Selecting a resin with consistent performance across scales can help maintain yield, minimize development risks, and support a smooth transition from bench to manufacturing. Our resin selection guide can help determine which resin is right for your purification process.

For various molecules or emerging modalities, custom resins can be developed to target specific binding profiles or workflow needs. These solutions help address challenges, such as low yield and purity, emerging targets, or molecule- and process-specific issues. Learn more about custom resin development.

Chromatography resins can be ordered directly through Thermo Fisher Scientific. For help with product selection, technical questions, or purchasing support, please contact us. Our team collaborates with biotech, biopharma, and CDMOs to align resin choices with development and commercial objectives.

Resins are available in prepacked column formats to simplify process development and scale-up. These formats save your lab time packing columns and support consistency and reproducibility, especially in labs with limited resources. Explore our chromatography columns.

To support accelerated timelines, screening tools, such as 96-well plates and RoboColumns prepacked columns, enable parallel testing and resin evaluation during early development. Contact us with any questions about early resin evaluation, and one of our specialists will be happy to support you in choosing the right tools.

Explore more chromatography resins

Thermo Fisher Scientific offers POROS ion-exchange, hydrophobic interaction, and mixed-mode chromatography resins for large-scale bioseparations, along with MabCaptureC and CaptureSelect affinity resins designed for efficient purification of mAbs, advanced antibody variants, recombinant proteins, mRNA, viruses, and other biologics.
 

Discover bioprocessing resources

Access resources that support resin evaluation and use across development stages. Whether you’re running early experiments, troubleshooting a single unit operation, or scaling a process, these tools can help inform decision-making.

Chromatography resources

Chromatography resources include content on the purification of antibodies, viral vectors, nucleic acids, proteins, and vaccines. It is designed to help scientists make more informed and accurate process decisions with information on resin performance and implementation in downstream workflows.

Bioprocessing resources

Our Bioprocessing Learning Center offers articles, white papers, and events that cover topics including antibodies, stem cells, viral vectors, vaccines, purification methods, and single-use bioreactors. These resources support biologics development from research through manufacturing.

Use of the products may vary. For specific use statements, please see product literature.