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Choosing a microplate reader that best suits your research needs
Thermo Scientific microplate readers offer flexibility, performance, and ease of use for a variety of microplate assays. From routine to challenging plate-based assays, we offer versatile and adaptable solutions for your research. Available detection modes include fluorescence, absorbance, turbidimetry, luminescence, time-resolved fluorescence (TRF), and AlphaScreen assays. Choosing the microplate reader that is right for you depends on your application, sample size, and overall laboratory needs. Explore the selection guide below and choose a model for more information.
Selection guide—Which reader fits best?
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| Overview | |||
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| Easy-to-use microplate photometer designed with over 40 years of experience with the well-known Multiskan product brand. This instrument provides proven performance and reliable results in an ELISA assays or in a variety of other research and routine applications through innovative detection design and built-in self-diagnostics. | The UV/VIS microplate spectrophotometer ideal for a variety of endpoint, kinetic and spectral assays. Equipped with large touchscreen for stand-alone use with ready-made assay protocols for the most common DNA, RNA, and protein assays. Offers access to Thermo Fisher Connect and Microsoft OneDrive cloud-based tools for secure and remote data management. | Versatile, entry level multimode microplate reader for variety of UV-vis absorbance, fluorescence, and luminescence microplate assays. SkanIt PC software with validated protocols and visual workflow guarantees ease of use and effortless data analysis. | A top-of-the-art multimode microplate reader offering up to five measurement technologies, including absorbance, fluorescence intensity, luminescence, time-resolved fluorescence and Alpha. Besides excellent performance in all applications, it offers huge selection of automatic features to help you save time and reduce common errors in the lab. |
| Detection technology | |||
| Absorbance, turbidimetry | Absorbance, turbidimetry | Absorbance, turbidimetry, fluorescence, luminescence | Absorbance, turbidimetry, fluorescence. Optional: time-resolved fluorescence (TRF), luminescence, Alpha Screen |
| Absorbance, filter based | |||
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| Absorbance, monochromator based | |||
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| Fluorescence intensity, filter based | |||
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| Fluorescence intensity, monochromator based | |||
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| Fluorescence intensity, top reading | |||
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| Fluorescence intensity, bottom reading | |||
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| Time-resolved fluorescence (TRF), filter based | |||
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| Luminescence, filter based | |||
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| Luminescence, monochromator based | |||
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| Luminescence, glow assays | |||
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| Luminescence, flash assays | |||
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| Alpha Screen, filter based | |||
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| Reagent dispensers | |||
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| CO2/O2 control | |||
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| Incubation, from ambient + 4 °C to 45 °C | |||
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| Shaking | |||
| Linear | Linear | Linear, orbital, double-orbital | Orbital |
| Microplate types | |||
| 96, 384 | 6-48*, 96, 384 | 6-48, 96, 384 | 6-48, 96, 384, 1536 |
| Cuvette port | |||
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| µDrop plate compatibility | |||
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| User interface | |||
| Color LCD or PC | Touch screen or PC | PC | PC |
| SkanIt software compatibility | |||
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| Automation compatibility | |||
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| Upgradeable | |||
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| 21 CFR Part 11 compliance | |||
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All Thermo Scientific microplate readers are paired with the powerful and intuitive SkanIt Software, enabling excellent usability and flexibility. The SkanIt software is license free and allows multiple users for operation and data processing.
| Single-mode readers | Multi-mode readers | |||
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| Overview | Basic filter-based absorbance reader; reliable, and budget-friendly for ELISAs and colorimetric assays. | Monochromator-based spectrophotometer; easy-to-use, and suitable for low-volume analysis with µDrop plates. | Versatile, entry-level multimode reader with robust absorbance, fluorescence, and luminescence detection. | Advanced multimode reader with up to 5 detection modes, automated optimization, and modular upgrades. |
| Detection modes | ||||
| Detection technology | Absorbance, turbidimetry | Absorbance, turbidimetry | Absorbance, turbidimetry, fluorescence, luminescence | Absorbance, turbidimetry, fluorescence. Optional: time-resolved fluorescence (TRF), luminescence, AlphaScreen |
| Monochromator-based modes | N/A | Absorbance | Absorbance | Absorbance, fluorescence, luminescence, TRF |
| Filter-based modes | Absorbance | N/A | Fluorescence, luminescence | Luminescence, TRF, AlphaScreen |
| Spectral scanning | N/A | Absorbance | Absorbance | Absorbance, fluorescence, luminescence, TRF |
| Reading option | Top | Top and Bottom | ||
| Automatic gain adjustment | |
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| Multi-point reading | |
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| Additional features | ||||
| Shaking | Linear | Linear | Linear, orbital, double-orbital | Orbital |
| Incubation, from ambient + 4 °C to 45 °C | |
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| Reagent dispensers | |
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| CO2/O2 control | |
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| Automation compatibility | |
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| 21 CFR Part 11 compliance | |
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| Upgradeable | |
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| Compatible labware | ||||
| Plate format | 96-well plates (384-wells optional) |
6-to 48-well plates*, 96- and 384-well plates | 6- to 48-, 96- and 384-well plates | 6- to 48-, 96-, 384- and 1536-well plates |
| µDrop and µDrop Duo plates | |
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| Cuvette port | |
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| General specification | ||||
| User interface | Color LCD or PC | Touch screen or PC | PC | PC |
| SkanIt software compatibility | |
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*Maximum plate height with lid is 19.5 mm
For Research Use Only. Not for use in diagnostic procedures.