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Gibco CTS Dynabeads Magnetic Beads for Cell Therapy

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Streamline T cell isolation and activation

T cell processing often involves variable starting materials and hands-on steps that can lead to manufacturing inconsistencies. Dynabeads cell separation technology offers a structured approach to establishing defined isolation and activation, helping teams develop more consistent upstream processes. By supporting controlled early interactions in closed, GMP-ready formats, Gibco CTS Dynabeads magnetic beads help programs build a reliable foundation for later manufacturing stages.

How CTS Dynabeads magnetic beads work

CTS Dynabeads magnetic beads support defined T cell isolation, activation, and depletion by bringing highly specific surface ligands into controlled contact with target cells. Built on a uniform paramagnetic structure, the beads help create steady interaction conditions during early processing steps, supporting reproducible isolation and activation within closed bioprocessing workflows.
 

Diagram describing how CTS Dynabeads magnetic beads work

 

Targeted binding Active release Magnetic removal Buffer exchange and cleanup 
Single-domain VHH antibodies on the bead surface bind defined CD markers to support selective T cell isolation or activation (1). After cell separation, the biotin-based Gibco CTS Detachable Dynabeads Release Buffer is added (2) to actively detach beads through a competitive displacement mechanism that releases the biotin derivative on the bead surface (3). Once detached, CTS Detachable Dynabeads magnetic beads can be magnetically collected and separated from the cell population (4). Subsequent washes remove the CTS Detachable Dynabeads Release Buffer and remaining components (5), helping generate a highly pure, viable T cell population, including subsets that maintain early memory or stem-like phenotypes.

Benefits of CTS Dynabeads magnetic beads

Establish reliable early T cell isolation and activation with Dynabeads cell separation technology that supports defined interactions from the start of the process. In addition to isolation and activation, the CTS Dynabeads portfolio includes CD3⁺ cell depletion solutions, expanding support for allogeneic T cell manufacturing workflows that require precise cell population control. The consistent bead composition and well-documented manufacturing framework help reduce cell therapy processing variability between runs and maintain steady operation as workflows evolve. This dependable performance offers programs a stable foundation for moving from development into larger-scale manufacturing.

CTS Detachable Dynabeads magnetic beads

Some T cell workflows require early activation and controlled bead release for modification and expansion. Gibco CTS Detachable Dynabeads magnetic beads address this need by combining selective binding with the option to release beads at a defined timepoint using the CTS Detachable Dynabeads Release Buffer. This approach helps teams manage activation windows with greater control and move into downstream steps without carrying beads forward. Designed for use in closed, GMP-ready systems, including the CTS DynaCellect Magnetic Separation System, the detachable format supports flexibility across autologous and allogeneic processes.

CTS Detachable Dynabeads CD4 beads

Isolate CD4⁺ T cells with Gibco CTS Detachable Dynabeads CD4 beads, which allow timed bead release with the CTS Detachable Dynabeads Release Buffer. This approach prepares defined CD4 subsets for downstream modification or expansion.
 

CTS Detachable Dynabeads CD8 beads

Isolate CD8⁺ T cells using positive selection with CTS Detachable Dynabeads CD8 beads that can be actively released with the CTS Detachable Dynabeads Release Buffer. This approach supports controlled subset isolation and fits into closed, automation-ready workflows.

CTS Detachable Dynabeads CD3/CD28 beads

Combine isolation and activation in one step by engaging CD3 and CD28 markers with Gibco CTS Detachable Dynabeads CD3/CD28 beads. This approach enables bead release at a chosen time, allowing better control over activation windows before advancing downstream T cell processes.

Gibco CTS Dynabeads magnetic beads

Established T cell processes often rely on solutions that support predictable activation and steady expansion throughout development. CTS Dynabeads magnetic beads offer a consistent option for programs that use a fixed-activation approach with passive bead release.

Gibco CTS Dynabeads CD3/CD28 beads

Support one-step T cell isolation and activation by engaging CD3 and CD28 markers with Dynabeads CD3/CD28 beads. This option was developed for workflows that do not require active bead release timing.


 

Dynabeads CD3 Depletion Prototype*

Target CD3⁺ cell populations with Dynabeads CD3 Depletion Prototype* to help reduce residual TCR expression and support downstream therapeutic performance in allogeneic T cell manufacturing workflows. They are designed for efficient, TCR positive cell removal, facilitating high recovery and viability of CD3⁻ target populations.

Gibco CTS Dynabeads Treg Xpander beads

Expand regulatory T cells (Tregs) with Dynabeads Treg Xpander. They support targeted activation and high-fold expansion while helping maintain FOXP3 expression, suppressive activity, and phenotype stability.


 

Designed for flexibility across T cell workflows

T cell manufacturing demands solutions that can adapt to differences in starting material, process scale, and production strategy. Dynabeads cell separation technology supports both autologous and allogeneic workflows by enabling consistent process variables that can be applied across varied cell therapy workflows.
 

Enhance processing with the Gibco CTS Dynabeads Release Buffer

Control bead release at the point you choose with the Dynabeads Release Buffer, designed for use with CTS Detachable Dynabeads magnetic beads. Its biotin-based competitive displacement mechanism enables active bead release at any stage. This supports process flexibility and helps teams manage purity, yield, and activation profiles before transitioning to downstream steps.
 

Optimize closed-system automation with the Gibco CTS DynaCellect Magnetic Separation System

Streamline T cell processing by integrating Dynabeads cell separation technology with the CTS DynaCellect Magnetic Separation System. It helps automate isolation, activation, and bead removal within a closed system, helping reduce manual touchpoints and maintain reproducibility across T cell workflows.

 

Enhance cell therapy workflows with connected solutions

Integrate Dynabeads cell separation technology with cell therapy products to support consistent handling from isolation through final processing.

Gibco CTS DynaCellect Magnetic Separation System

Automate magnetic separation steps with the CTS DynaCellect Magnetic Separation System, designed to support consistent isolation, activation, and bead removal across T cell workflows.
 

Gibco CTS Rotea Counterflow Centrifugation System

Perform washing, concentration, and separation steps with the CTS Rotea Counterflow Centrifugation System, suited for development and clinical manufacturing.

 

Gibco CTS Xenon Electroporation System

Support closed, scalable transfection with the CTS Xenon Electroporation System, designed for efficient delivery of DNA, RNA, and proteins with strong viability and recovery across development and manufacturing workflows.

Frequently asked questions

CTS Dynabeads magnetic beads are used to isolate and activate T cells through defined CD3/CD28 engagement in closed, GMP-ready workflows. They support early steps in both autologous and allogeneic manufacturing and are part of a portfolio of cell therapy products designed to be used together.

CTS Dynabeads magnetic beads are designed to activate T cells by bringing CD3 and CD28 markers into close proximity, enabling coordinated signaling required for defined activation. When the beads bind to the cell surface, this clustering event initiates early signaling pathways that guide proliferation and phenotype development. Because the beads can be magnetically separated without centrifugation, activation steps can be performed in closed systems, enabling consistent handling across runs.

Dynabeads cell separation technology has been incorporated into the manufacturing process for FDA-approved CAR-T therapies, particularly in processes involving T cell isolation, activation, and expansion within commercial manufacturing workflows. CTS Dynabeads magnetic beads are intended for research use or further manufacturing, consistent with regulatory requirements for cell-based therapeutics.

CTS Detachable Dynabeads CD3/CD28 beads include an active, biotin-based release mechanism that allows users to remove beads from T cells at their selected time using the CTS Dynabeads Release Buffer. This active release offers greater control over isolation and activation steps and can shorten bead removal times. Standard CTS Dynabeads CD3/CD28 beads use passive bead release, after which the beads are magnetically separated, and therefore do not offer timed, user-directed detachment.

CTS Detachable Dynabeads magnetic beads can be used in both autologous and allogeneic T cell workflows. Their active release mechanism supports process designs that require controlled bead removal, making them adaptable across different manufacturing approaches.

CTS Detachable Dynabeads magnetic beads are designed to work directly with the CTS DynaCellect Magnetic Separation System for closed, automated processing. They can also be used with Gibco CTS DynaMag Magnets for small-scale or early development workflows, allowing flexibility across process stages while maintaining consistent handling conditions.

Discover cell therapy bioprocessing solutions

Explore cell therapy bioprocessing solutions that help maintain consistency as programs progress from development to manufacturing and adapt to autologous or allogeneic needs.

Cell therapy resources


Explore cell therapy resources for in-depth workflow guidance, application notes, and technical materials that support T cell processing from early development through manufacturing.
 

Enhance your cell therapy workflow with CTS Dynabeads magnetic beads

*For Research Use Only. Not for use in diagnostic procedures. Product is a prototype and performance characteristics of this product have not been established.

For Research Use or Manufacturing of Cell, Gene, or Tissue-Based Products. CAUTION: Not intended for direct administration into humans or animals.