Gibco™

CTS™ Dynabeads™ Treg Xpander

Catalog number:  46000D

 Related applications:

Primary Cell Culture

Error loading your content!

  Catalog number
Select a plan
Unit size
Price ({{currency}}) Availability Qty
{{product.sku}} {{product.sku}} also known as {{product.formattedSku}} 
{{product.availability.message}}
Pro add-ons

Your on-site stock

›› {{supplyCenter.scName}}({{scProduct.stockOnHand}} In stock)
›› {{supplyCenter.scName}}(Out of stock)
›› {{supplyCenter.scName}}
This item is not currently available on-site. Depending on your Supply Center settings you may be able to add the item to cart above else use the Order Non-Stocked Items' tab on the Supply Center home page.
Back to top

Description

Optimized for the ex vivo activation and expansion of regulatory T cells (Tregs), CTS Dynabeads Treg Xpander provides more specific and higher fold expansion compared to our CTS Dynabeads CD3/CD28. Tregs activated and expanded with this product show suppressive activity and display the characteristic Treg cytokine profile and phenotype. Furthermore, high stability of the expanded Tregs has been demonstrated through analysis of the Treg-specific demethylated region.

CTS Dynabeads Treg Xpander features include:
• Aseptically manufactured and ready for clinical trials and cell therapy manufacturing process development
• Drug Master File (DMF) to cross-reference in IND applications
• >800 fold expansion after two stimulations
• Treg phenotype (FOXP3) and suppressive function maintained

Regulatory T cells (CD4+ CD25+ FOXP3+) are a suppressive subset of CD4+ T helper cells and are important for the regulation of immune responses. Due to a relative frequency of 1–2% of the total lymphocyte population, ex vivo expansion of Tregs prior to adoptive transfer is expected for most clinical applications.

For Research Use or Non-Commercial Manufacturing of Cell-Based Products for Clinical Research. CAUTION: Not intended for direct administration to humans or animals.

Specifications

Cell Type: T Cells (Regulatory)
Product Line: Dynabeads™
Product Size: 1 vial
Target Species: Human
Shipping Condition: Wet Ice

Contents & storage

10 mL CTS Dynabeads Treg Xpander, 2x108 beads/mL, store at 2–8°C

Documents

Manuals & protocols