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Rational design leveraging routine, high-resolution protein structure determination is driving the discovery and development of a diverse range of small molecule and biologic therapies. Cryo-electron microscopy (cryo-EM) has rapidly become the go-to method for drug discovery, delivering critical structural insights that support powerful breakthroughs on a variety of targets, many of which were once considered intractable.
Cryo-EM can help reduce late-stage trial failures by determining high-resolution drug target structures and defining the mechanism of action at early discovery stages. Structure-based drugs have two times the rate of clinical success at 50% of preclinical time and cost.
Get the Cryo-EM in Drug Discovery eBook
This eBook highlights recent examples of how cryo-EM and structural insights are being used across various therapeutic modalities to advance drug discovery pipelines. Download this eBook to see the impact of cryo-EM on:
- Small molecule therapeutics
- Vaccine design and drug delivery
- Understanding complex diseases with cutting-edge cryo-EM
- Decoding tauopathies
- Notable public disclosures on clinical stage assets