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Proteintech
5 Lipoxygenase Polyclonal Antibody
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Product Details
10021-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Amount
79.5 µg
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Target Information
This gene encodes a protein which, with Arachidonate 5-lipoxygenase-activating protein, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 5-lipoxygenase; 5-LO; Arachidonate 5-lipoxygenase; arachidonic acid 5-lipoxygenase; leukotriene A4 synthase; lipoxygenase; LOX-5; lox5; Polyunsaturated fatty acid 5-lipoxygenase; RP11-67C2.3
Gene Aliases: 5-LO; 5-LOX; 5LO; 5LPG; 5LX; AI850497; ALOX5; F730011J02; LOG5
UniProt ID: (Human) P09917, (Mouse) P48999
Entrez Gene ID: (Human) 240, (Mouse) 11689
arachidonate 5-lipoxygenase activity
arachidonate 12-lipoxygenase activity
iron ion binding
protein binding
oxidoreductase activity
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
hydrolase activity
arachidonate 8(S)-lipoxygenase activity
metal ion binding
dioxygenase activity
oxygenase
long-chain fatty acid metabolic process
negative regulation of endothelial cell proliferation
leukocyte chemotaxis involved in inflammatory response
leukocyte migration involved in inflammatory response
leukotriene production involved in inflammatory response
lipid metabolic process
icosanoid metabolic process
leukotriene metabolic process
response to stress
inflammatory response
humoral immune response
negative regulation of angiogenesis
arachidonic acid metabolic process
leukotriene biosynthetic process
lipoxygenase pathway
positive regulation of bone mineralization
lipid oxidation
dendritic cell migration
glucose homeostasis
long-chain fatty acid biosynthetic process
regulation of fat cell differentiation
regulation of inflammatory response
negative regulation of inflammatory response
regulation of insulin secretion
negative regulation of vascular wound healing
negative regulation of wound healing
regulation of inflammatory response to wounding
regulation of cytokine production involved in inflammatory response
regulation of cellular response to oxidative stress
leukotriene A4 biosynthetic process
regulation of reactive oxygen species biosynthetic process
negative regulation of response to endoplasmic reticulum stress
negative regulation of sprouting angiogenesis
positive regulation of leukocyte adhesion to arterial endothelial cell
lipoxin biosynthetic process
acute inflammatory response
sensory perception of pain
positive regulation of vasoconstriction
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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