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p27Kip1 (Mitotic Inhibitor/Suppressor Protein) Recombinant Mouse Monoclonal Antibody (r1B4)
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FIGURE: 1 / 2
p27Kip1 (Mitotic Inhibitor/Suppressor Protein) Antibody (1027-MSM12-P0) in IHC (P)
Immunohistochemistry (Paraffin) analysis performed in formalin fixed, paraffin-embedded human placenta stained with p27Kip1 Recombinant Mouse Monoclonal Antibody (rCDKN1B/13245). Inset: PBS instead of primary antibody; secondary only negative control.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
1027-MSM12-P0
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
r1B4
Immunogen
Recombinant human CDKN1B protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Amount
20 µg
Purification
Protein A
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDKN1B; CDN1B; cyclin-dependent kinase inhibitor 1B (p27, Kip1); Cyclin-dependent kinase inhibitor p27 Kip1; P27 CDKN1B; p27(KIP1); unnamed protein product
Gene Aliases: CDKN4; KIP1; MEN1B; MEN4; P27KIP1
UniProt ID: (Human) P46527
Entrez Gene ID: (Human) 1027
protein kinase inhibitor activity
cyclin-dependent protein serine/threonine kinase inhibitor activity
protein binding
protein kinase binding
protein phosphatase binding
cyclin-dependent protein kinase activating kinase regulator activity
cyclin binding
ubiquitin protein ligase binding
macromolecular complex binding
chaperone binding
binding, bridging
molecular function inhibitor activity
ubiquitin ligase activator activity
regulation of cyclin-dependent protein serine/threonine kinase activity
G1/S transition of mitotic cell cycle
signal transduction
heart development
negative regulation of cell proliferation
negative regulation of cell growth
DNA damage response, signal transduction by p53 class mediator
positive regulation of protein catabolic process
positive regulation of DNA replication
negative regulation of growth
negative regulation of mitotic cell cycle
autophagic cell death
negative regulation of epithelial cell proliferation
nuclear export
regulation of cell cycle
cellular response to lithium ion
cellular senescence
regulation of mitotic cell cycle phase transition
regulation of cell cycle G1/S phase transition
negative regulation of vascular smooth muscle cell proliferation
negative regulation of cardiac muscle tissue regeneration
regulation of G1/S transition of mitotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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