'As the expression of cyclin D1 is induced during liver regeneration and also in hepatic tumor cells, cyclin D1 is likely to play an important role in the proliferation and transformation of hepatocytes. However, the role of cyclin D1 in liver development remains unknown. Here we show that the expression ... More
Human Cytomegalovirus Induces Drug Resistance and Alteration of Programmed Cell Death by Accumulation of Delta N-p73alpha.
Authors Allart Sophie; Martin Helene; Detraves Claire; Terrasson Jerome; Caput Daniel; Davrinche Christian;
JournalJ Biol Chem
PubMed ID12034725
'Intrauterine transmission of human cytomegalovirus (HCMV) to the fetus following primary infection in early and late pregnancy usually results in severe neurological handicaps and sensorineural hearing loss with typical migrational anomalies, optic atrophy, disturbed myelination, cerebella hypoplasia, microcephaly, hydrocephaly, and lissencephaly. Recently, evidences raised from the phenotype of p73-deficient mice ... More
Opposing actions of inositol 1,4,5-trisphosphate and ryanodine receptors on nuclear factor of activated T-cells regulation in smooth muscle.
AuthorsGomez MF, Stevenson AS, Bonev AD, Hill-Eubanks DC, Nelson MT,
JournalJ Biol Chem
PubMed ID12145283
'The nuclear factor of activated T-cells (NFAT), originally identified in T-cells, has since been shown to play a role in mediating Ca(2+)-dependent gene transcription in diverse cell types outside of the immune system. We have previously shown that nuclear accumulation of NFATc3 is induced in ileal smooth muscle by platelet-derived ... More
A TRP Channel that Senses Cold Stimuli and Menthol.
Authors Peier Andrea M; Moqrich Aziz; Hergarden Anne C; Reeve Alison J; Andersson David A; Story Gina M; Earley Taryn J; Dragoni Ilaria; McIntyre Peter; Bevan Stuart; Patapoutian Ardem;
JournalCell
PubMed ID11893340
'A distinct subset of sensory neurons are thought to directly sense changes in thermal energy through their termini in the skin. Very little is known about the molecules that mediate thermoreception by these neurons. Vanilloid Receptor 1 (VR1), a member of the TRP family of channels, is activated by noxious ... More
Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site.
AuthorsStrotmann R, Schultz G, Plant TD,
JournalJ Biol Chem
PubMed ID12724311
Most Ca2+-permeable ion channels are inhibited by increases in the intracellular Ca2+ concentration ([Ca2+]i), thus preventing potentially deleterious rises in [Ca2+]i. In this study, we demonstrate that currents through the osmo-, heat- and phorbol ester-sensitive, Ca2+-permeable nonselective cation channel TRPV4 are potentiated by intracellular Ca2+. Spontaneous TRPV4 currents and currents ... More
An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth.
Authors Weihua Zhang; Lathe Richard; Warner Margaret; Gustafsson Jan-Ake;
JournalProc Natl Acad Sci U S A
PubMed ID12370428
Epithelial proliferation of the ventral prostate in rodents peaks between 2 and 4 weeks of age, and by week 8, proliferating cells are rare. We have used ERbeta(-/-) and CYP7B1(-/-) mice to investigate the role of ERbeta and one of its ligands, 5alpha-androstane-3beta,17beta-diol (3betaAdiol), in growth of the ventral prostate. ... More
The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63.
Authors Calabrò Viola; Mansueto Gelsomina; Parisi Tiziana; Vivo Maria; Calogero Raffaele A; La Mantia Girolama;
JournalJ Biol Chem
PubMed ID11714701
Genetic alteration of the p53 tumor suppressor gene, which monitors DNA damage and operates cell cycle checkpoints, is a major factor in the development of human malignancies. The p53 protein belongs to a family that also includes two structurally related proteins, p63 and p73. Although all three proteins share similar ... More
Cooperation of STAT-1 and IRF-1 in interferon-gamma-induced transcription of the gp91(phox) gene.
Authors Kumatori Atsushi; Yang Dan; Suzuki Shoichi; Nakamura Michio;
JournalJ Biol Chem
PubMed ID11781315
Interferon (IFN)-gamma induces the expression of the gp91(phox) gene both during myeloid differentiation and also in mature phagocytes through several cis-elements and their binding proteins. To find new cis-elements for this induction, transient expression assays were performed using a reporter gene driven by serially truncated gp91(phox) promoters in U937 cells. ... More
A virus discovery method incorporating DNase treatment and its application to the identification of two bovine parvovirus species.
Authors Allander T; Emerson S U; Engle R E; Purcell R H; Bukh J;
JournalProc Natl Acad Sci U S A
PubMed ID11562506
Identification of previously unrecognized viral agents in serum or plasma samples is of great medical interest but remains a major challenge, primarily because of abundant host DNA. The current methods, library screening or representational difference analysis (RDA), are very laborious and require selected sample sets. We have developed a simple ... More
Focal Adhesion Kinase Activated by beta 4 Integrin Ligation to mCLCA1 Mediates Early Metastatic Growth.
Early metastatic growth occurs at sites of vascular arrest of blood-borne cancer cells and is entirely intravascular. Here we show that lung colonization by B16-F10 cells is licensed by beta(4) integrin adhesion to the mouse lung endothelial Ca(2+)-activated chloride channel protein mCLCA1. In a manner independent of Met, beta(4) integrin-mCLCA1-ligation ... More
Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6.
Authors Xie Yue; Chen Changmin; Stevenson Mary Ann; Auron Philip E; Calderwood Stuart K;
JournalJ Biol Chem
PubMed ID11801594
Heat shock factor (HSF) 1 is the major heat shock transcription factor that regulates stress-inducible synthesis of heat shock proteins and is also essential in protection against endotoxic shock. Following our previous study, which demonstrated the transcriptional repression of the IL-1beta gene by HSF1 (Cahill, C. M., Waterman, W. R., ... More