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Proteintech
SLC25A13 Polyclonal Antibody
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Product Details
10789-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SLC25A13 Fusion Protein Ag1242 (336-675 aa encoded by BC006566)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Amount
45 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SVAGAVGAT AVYPIDLVKT RMQNQRSTGS FVGELMYKNS FDCFKKVLRY EGFFGLYRGL LPQLLGVAPE KAIKLTVNDF VRDKFMHKDG SVPLAAEILA GGCAGGSQVI FTNPLEIVKI RLQVAGEITT GPRVSALSVV RDLGFFGIYK GAKACFLRDI PFSAIYFPCY AHVKASFANE DGQVSPGSLL LAGAIAGMPA ASLVTPADVI KTRLQVAARA GQTTYSGVID CFRKILREEG PKALWKGAGA RVFRSSPQFG VTLLTYELLQ RWFYIDFGGV KPMGSEPVPK SRINLPAPNP DHVGGYKLAV ATFAGIENKF GLYLPLFKPS VSTSKAIGGG P (336-675 aa encoded by BC006566)
Target Information
Citrin, also known as SLC25A13 (Solute carrier family 25 member 13), ARALAR2 or CTLN2, is a 675 amino acid multi-pass membrane protein that localizes to the inner membrane of the mitochondrion. Expressed in liver, pancreas, kidney, brain, heart and placenta, citrin functions as a calcium-dependent glutamate and aspartate carrier that is thought to play a role in the urea cycle. Citrin, a member of the mitochondrial carrier family, contains three Solcar repeats and four EF-hand domains through which it binds calcium. Defects in the gene encoding citrin are the cause of citrullinemia type 2 (CTLN2) and neonatal intrahepatic cholestasis due to citrin deficiency (NICCD). CTLN2 is an autosomal recessive disease that results from errors in the urea cycle and is characterized by neuropsychiatric symptoms such as loss of memory, seizures and coma. NICCD, a non-lethal disorder, occurs during infancy and is characterized by low birth weight, reduced bile flow, growth retardation and hepatic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARALAR-related gene 2; aralar2; Calcium-binding mitochondrial carrier protein Aralar2; Citrin; citrullinemia type II; Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial; Mitochondrial aspartate glutamate carrier 2; putative calcium-dependent mitochondrial carrier protein; solute carrier family 25 (aspartate/glutamate carrier), member 13; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13; Solute carrier family 25 member 13; solute carrier family 25, member 13; solute carrier family 25, member 13 (citrin); unnamed protein product
Gene Aliases: AGC2; AI785475; ARALAR2; CITRIN; CTLN2; Ctrn; NICCD; RGD1565889; SLC25A13
UniProt ID: (Human) Q9UJS0, (Mouse) Q9QXX4, (Rat) F1LZW6
Entrez Gene ID: (Human) 10165, (Mouse) 50799, (Rat) 362322
3-sulfino-L-alanine: proton, glutamate antiporter activity
aspartate:glutamate, proton antiporter activity
L-glutamate transmembrane transporter activity
calcium ion binding
protein binding
acidic amino acid transmembrane transporter activity
L-aspartate transmembrane transporter activity
identical protein binding
metal ion binding
molecular_function
transporter
secondary carrier transporter
gluconeogenesis
ATP biosynthetic process
mitochondrial transport
neutral amino acid transport
aspartate transport
L-glutamate transport
malate-aspartate shuttle
cellular respiration
response to calcium ion
transmembrane transport
L-aspartate transmembrane transport
hydrogen ion transmembrane transport
transport
L-glutamate transmembrane transport
L-aspartate transmembrane transport
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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