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CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Recombinant Mouse Monoclonal Antibody (rCFTR/8048)
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FIGURE: 1 / 1
CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Antibody (1080-MSM17-P0) in IHC (P)
IHC analysis of formalin-fixed, paraffin-embedded human pancreas. CFTR Recombinant Mouse Monoclonal Antibody (rCFTR/8048). Inset: PBS instead of primary antibody; secondary only negative control.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
1080-MSM17-P0
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
rCFTR/8048
Immunogen
Recombinant fragment (around aa550-850) of human CFTR protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Amount
20 µg
Purification
Protein A/G
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control: Human pancreas kidney or placenta.
Cellular Location: Cell Surface. Cytoplasm.
Target Information
Cystic Fibrosis (CF) is a common lethal genetic disease caused by mutations of the gene coding for the cystic fibrosis transmembrane conductance factor, a cAMP regulated chloride channel. Approximately 70% of all CF cases share the deletion of a phenylalanine at position 508 (delta F508) which results in abnormal chloride transport. Since the CF mutation is lethal, most often by lung and liver disease, it raises the question of why this genetic disease remains as common as it is. One possible explanation is that Salmonella typhi has been shown to use CFTR to enter intestinal epithelial cells and that delta F508 heterozygote and homozygote mice showed 86% and 100% reductions in S. typhi intestinal submucosal uptake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP Binding Cassette Superfamily C Member 7 (ABCC7); cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulating; cystic fibrosis transmembrane conductance regulator; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); cystic fibrosis transmembrane conductance regulator isoform; tcag7.78; TNR CFTR
Gene Aliases: ABC35; ABCC7; CF; CFTR/MRP; dJ760C5.1; MRP7; TNR-CFTR
UniProt ID: (Human) P13569
Entrez Gene ID: (Human) 1080
chloride channel activity
channel-conductance-controlling ATPase activity
protein binding
ATP binding
bicarbonate transmembrane transporter activity
chloride transmembrane transporter activity
ATPase activity
chloride channel regulator activity
chloride channel inhibitor activity
enzyme binding
PDZ domain binding
ATPase activity, coupled to transmembrane movement of substances
chaperone binding
14-3-3 protein binding
Sec61 translocon complex binding
ABC-type transporter activity
ion transport
chloride transport
water transport
bicarbonate transport
ion transmembrane transport
response to endoplasmic reticulum stress
transepithelial water transport
sperm capacitation
multicellular organismal water homeostasis
intracellular pH elevation
transmembrane transport
membrane hyperpolarization
positive regulation of enamel mineralization
cellular response to cAMP
amelogenesis
chloride transmembrane transport
cellular response to forskolin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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