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Proteintech
VDAC1/2 Polyclonal Antibody
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Product Details
10866-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Insect,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
VDAC1/2 Fusion Protein Ag1144 (1-283 aa encoded by BC008482)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This polyclonal antibody raised against full-length human VDAC1 protein can cross react with VDAC2.
Immunogen sequence: MAVPPTYAD LGKSARDVFT KGYGFGLIKL DLKTKSENGL EFTSSGSANT ETTKVTGSLE TKYRWTEYGL TFTEKWNTDN TLGTEITVED QLARGLKLTF DSSFSPNTGK KNAKIKTGYK REHINLGCDM DFDIAGPSIR GALVLGYEGW LAGYQMNFET AKSRVTQSNF AVGYKTDEFQ LHTNVNDGTE FGGSIYQKVN KKLETAVNLA WTAGNSNTRF GIAAKYQIDP DACFSAKVNN SSLIGLGYTQ TLKPGIKLTL SALLDGKNVN AGGHKLGLGL EFQA (1-283 aa encoded by BC008482)
Target Information
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B36-VDAC; epididymis secretory sperm binding protein; mVDAC1; mVDAC5; Non-selective voltage-gated ion channel VDAC1; Non-selective voltage-gated ion channel VDAC2; Outer mitochondrial membrane protein porin 1; Outer mitochondrial membrane protein porin 2; Plasmalemmal porin; Porin 31HL; Porin 31HM; rVDAC1; sperm binding protein 1a; unnamed protein product; VDAC-1; VDAC-2; VDAC-5; VDAC-6; VDAC2; Voltage-dependent anion-selective channel protein 1; voltage-dependent anion-selective channel protein 2; Voltage-dependent anion-selective channel protein 5; Voltage-dependent anion-selective channel protein 6
Gene Aliases: AL033343; mVDAC2; mVDAC6; POR; PORIN; VDAC; VDAC-1; VDAC1; VDAC2; Vdac5; Vdac6
UniProt ID: (Human) P21796, (Human) P45880, (Mouse) Q60932, (Rat) Q9Z2L0, (Mouse) Q60930, (Rat) P81155
Entrez Gene ID: (Human) 7416, (Human) 7417, (Mouse) 22333, (Rat) 83529, (Mouse) 22334, (Rat) 83531
nucleotide binding
voltage-gated ion channel activity
protein binding
ATP binding
oxysterol binding
lipid binding
voltage-gated anion channel activity
porin activity
cholesterol binding
protein kinase binding
phosphatidylcholine binding
identical protein binding
ion channel binding
ceramide binding
phospholipid scramblase activity
anion channel activity
protein complex binding
voltage-gated ion channel
behavioral fear response
ion transport
anion transport
lipid transport
apoptotic process
chemical synaptic transmission
neuron-neuron synaptic transmission
learning
epithelial cell differentiation
calcium ion transmembrane import into mitochondrion
positive regulation of apoptotic process
negative regulation of apoptotic process
transmembrane transport
anion transmembrane transport
negative regulation of calcium import into the mitochondrion
regulation of mitophagy
regulation of mitophagy
positive regulation of type 2 mitophagy
mitochondrial transmembrane transport
negative regulation of reactive oxygen species metabolic process
binding of sperm to zona pellucida
phospholipid scrambling
phospholipid translocation
mitochondrial outer membrane permeabilization
transport
mitochondrial calcium ion transport
regulation of anion transport
regulation of anion transmembrane transport
ion transmembrane transport
regulation of ion transmembrane transport
negative regulation of protein polymerization
negative regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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