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Proteintech
NPTX2 Polyclonal Antibody
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Product Details
10889-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NPTX2 Fusion Protein Ag1326 (1-350 aa encoded by BC009924)
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLALLAASV ALAVAAGAQD SPAPGSRFVC TALPPEAVHA GCPLPAMPMQ GGAQSPEEEL RAAVLQLRET VVQQKETLGA QREAIRELTG KLARCEGLAG GKARGAGATG KDTMGDLPRD PGHVVEQLSR SLQTLKDRLE SLEHQLRANV SNAGLPGDFR EVLQQRLGEL ERQLLRKVAE LEDEKSLLHN ETSAHRQKTE STLNALLQRV TELERGNSAF KSPDAFKVSL PLRTNYLYGK IKKTLPELYA FTICLWLRSS ASPGIGTPFS YAVPGQANEI VLIEWGNNPI ELLINDKVAQ LPLFVSDGKW HHICVTWTTR DGMWEAFQDG EKLGTGENLA PWHPIKPGGV L (1-350 aa encoded by BC009924)
Target Information
Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson's disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: apexin; neuro activity regulated petaxin; neuronal activity-regulated pentaxin; neuronal activity-regulated pentraxin; neuronal pentraxin 2; Neuronal pentraxin II; Neuronal pentraxin-2; NP-II; NP2
Gene Aliases: NARP; NP-II; NP2; NPTX2
UniProt ID: (Human) P47972, (Mouse) O70340
Entrez Gene ID: (Human) 4885, (Rat) 288475, (Mouse) 53324
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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