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NeoBiotechnologies
Chromogranin A/CHGA (Neuroendocrine Marker) Recombinant Mouse Monoclonal Antibody (rCHGA/9612)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
1113-MSM31-P0
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b, kappa
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
rCHGA/9612
Immunogen
Recombinant full-length human CHGA protein.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
200 µg/mL
Amount
20 µg
Purification
Protein A
Storage buffer
PBS with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive Control:Adrenal gland, thyroid, bowel, pancreas or pheochromocytoma. PC12 cells.
Cellular Location: Cytoplasmic vesicle; Neuronal dense core vesicle; Secreted; Secretory vesicle
Target Information
Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: betagranin (N-terminal fragment of chromogranin A); catestatin; chromofungin; chromogranin A; chromogranin A precursor; CTNNB; DKFZp686D02253; FLJ25606; FLJ37923; MGC105435; parathyroid secretory protein 1; pituitary secretory protein I; SP-I; unnamed protein product
Gene Aliases: CGA; PHE5; PHES
UniProt ID: (Human) P10645
Entrez Gene ID: (Human) 1113
regulation of the force of heart contraction
mast cell chemotaxis
regulation of blood pressure
negative regulation of catecholamine secretion
defense response to bacterium
mast cell degranulation
innate immune response
mast cell activation
negative regulation of insulin secretion
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive regulation of cardiac muscle contraction
adenylate cyclase-activating adrenergic receptor signaling pathway
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of relaxation of cardiac muscle
positive regulation of dense core granule biogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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