Rice phosphate transporters include an evolutionarily divergent gene specifically activated in arbuscular mycorrhizal symbiosis.
Authors Paszkowski Uta; Kroken Scott; Roux Christophe; Briggs Steven P;
JournalProc Natl Acad Sci U S A
PubMed ID12271140
'Using a genome-wide approach, we asked how many transporter genes contribute to symbiotic phosphate uptake and analyzed their evolutionary conservation. Considering the sequenced rice genome at hand, only the Oryza sativa phosphate transporter (OsPT) gene OsPT11 was specifically induced during the arbuscular mycorrhizal symbiosis. This induction was confined to the ... More
Relation between kidney function, proteinuria, and adverse outcomes.
AuthorsHemmelgarn BR, Manns BJ, Lloyd A, James MT, Klarenbach S, Quinn RR, Wiebe N, Tonelli M
JournalJAMA
PubMed ID20124537
'The current staging system for chronic kidney disease is based primarily on estimated glomerular filtration rate (eGFR) with lower eGFR associated with higher risk of adverse outcomes. Although proteinuria is also associated with adverse outcomes, it is not used to refine risk estimates of adverse events in this current system.' ... More
Factor B and the mitochondrial ATP synthase complex.
Authors Belogrudov Grigory I; Hatefi Youssef;
JournalJ Biol Chem
PubMed ID11744738
Factor B is a subunit of the mammalian ATP synthase complex, whose existence has been controversial. This paper describes the molecular and functional properties of a recombinant human factor B, which when added to bovine submitochondrial particles depleted of their factor B restores the energy coupling activity of the ATP ... More
Mycobacterium-inducible Nramp in striped bass (Morone saxatilis).
AuthorsBurge EJ, Gauthier DT, Ottinger CA, Van Veld PA,
JournalInfect Immun
PubMed ID14977970
In mammals, the natural resistance-associated macrophage protein 1 gene, Nramp1, plays a major role in resistance to mycobacterial infections. Chesapeake Bay striped bass (Morone saxatilis) is currently experiencing an epizootic of mycobacteriosis that threatens the health of this ecologically and economically important species. In the present study, we characterized an ... More
Dynamics of Pleistocene population extinctions in Beringian brown bears.
The climatic and environmental changes associated with the last glaciation (90,000 to 10,000 years before the present; 90 to 10 ka B.P.) are an important example of the effects of global climate change on biological diversity. These effects were particularly marked in Beringia (northeastern Siberia, northwestern North America, and the ... More
Differential nucleocytoplasmic trafficking between the related endocytic proteins Eps15 and Eps15R.
Authors Poupon Viviane; Polo Simona; Vecchi Manuela; Martin Gwendal; Dautry-Varsat Alice; Cerf-Bensussan Nadine; Di Fiore Pier Paolo; Benmerah Alexandre;
JournalJ Biol Chem
PubMed ID11777906
Eps15 and Eps15R are constitutive components of clathrin-coated pits that are required for clathrin-dependent endocytosis. The most striking difference between these two related proteins is that Eps15R is also found in the nucleus, whereas Eps15 is excluded from this compartment at steady state. To better understand the individual functions of ... More
Mutation screening in 86 known X-linked mental retardation genes by droplet-based multiplex PCR and massive parallel sequencing.
AuthorsHu H, Wrogemann K, Kalscheuer V, Tzschach A, Richard H, Haas SA, Menzel C, Bienek M, Froyen G, Raynaud M, Van Bokhoven H, Chelly J, Ropers H, Chen W
JournalHugo J
PubMed ID21836662
Massive parallel sequencing has revolutionized the search for pathogenic variants in the human genome, but for routine diagnosis, re-sequencing of the complete human genome in a large cohort of patients is still far too expensive. Recently, novel genome partitioning methods have been developed that allow to target re-sequencing to specific ... More