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Proteintech
TRAF7 Polyclonal Antibody
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Product Details
11780-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TRAF7 Fusion Protein Ag2414 (70-420 aa encoded by BC024267)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Amount
25.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: QAALQDSMP PISTPRRSDS AISVRSLHSE SSMSLRSTFS LPEEEEEPEP LVFAEQPSVK LCCQLCCSVF KDPVITTCGH TFCRRCALKS EKCPVDNVKL TVVVNNIAVA EQIGELFIHC RHGCRVAGSG KPPIFEVDPR GCPFTIKLSA RKDHEGSCDY RPVRCPNNPS CPPLLRMNLE AHLKECEHIK CPHSKYGCTF IGNQDTYETH LETCRFEGLK EFLQQTDDRF HEMHVALAQK DQEIAFLRSM LGKLSEKIDQ LEKSLELKFD VLDENQSKLS EDLMEFRRDA SMLNDELSHI NARLNMGILG SYDPQQIFKC KGTFVGHQGP VWCLCVYSMG DLLFSGSSDK TI (70-420 aa encoded by BC024267)
Target Information
TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670 A. A protein, is a human homolog of mouse Traf7 andconsists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways. It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp586I021; E3 ubiquitin-protein ligase TRAF7; MGC7807; ring finger and WD repeat domain 1; RING finger and WD repeat-containing protein 1; RING finger protein 119; RING, zinc finger and WD40 repeats containing protein; RING-type E3 ubiquitin transferase TRAF7; TNF receptor-associated factor 7; TNF receptor-associated factor 7, E3 ubiquitin protein ligase; traf7; unnamed protein product
Gene Aliases: CAFDADD; RFWD1; RGD1559653; RNF119; TRAF7
UniProt ID: (Human) Q6Q0C0
Entrez Gene ID: (Human) 84231, (Rat) 360491, (Mouse) 224619
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
metal ion binding
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
regulation of transcription from RNA polymerase II promoter
apoptotic process
I-kappaB kinase/NF-kappaB signaling
protein ubiquitination
protein K29-linked ubiquitination
positive regulation of MAPK cascade
positive regulation of neuron apoptotic process
positive regulation of protein metabolic process
regulation of ERK1 and ERK2 cascade
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of apoptotic signaling pathway
negative regulation of transcription from RNA polymerase II promoter
activation of MAPKKK activity
regulation of protein localization
positive regulation of protein sumoylation
cellular response to interleukin-6
transcription, DNA-templated
regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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