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Clusterin/Apolipoprotein J (APO-J) Recombinant Mouse Monoclonal Antibody (rCLU/9149)

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Clusterin/Apolipoprotein J (APO-J) Recombinant Mouse Monoclonal Antibody (rCLU/9149)

Product Details

1191-MSM26-P0

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b, kappa

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

rCLU/9149

Immunogen

Recombinant fragment (around aa410-440) of human CLU protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Amount

20 µg

Purification

Protein A/G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive Control: Human pancreas tonsil or cervix.

Cellular Location: cytosol. Microsome. Endoplasmic reticulum. Cytopla; Secreted. Can retrotranslocate from secretory compartments to cytosol upon cellular stress and Nucleus. Cytoplasm. Mitochondrion membrane. Cytoplasm

Target Information

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Aging associated protein 4; aging-associated protein 4; apo j; Apo J a; Apo J alpha; Apo J b; Apo J beta; Apo J α; Apo J β; Apo Ja; Apo Jb; ApoJ a; ApoJ alpha; ApoJ b; ApoJ beta; ApoJ α; ApoJ β; ApoJa; ApoJb; apolipoprotein J; apolipoprotein J precursor; Clusterin alpha / beta chain; Complement associated protein SP40; complement cytolysis inhibitor; complement cytolysis inhibitor precursor; complement lysis inhibitor; complement-associated protein SP-40,40; epididymis secretory sperm binding protein; GP80; HGNC:2095; ku70-binding protein 1; Ku70-binding protein 1 (KUB1); MGC24903; sulfated glycoprotein 2; Sulfated glycoprotein 2 (SGP2); Testosterone repressed prostate message 2 (TPRM2B); testosterone-repressed prostate message 2; TRPM-2; unnamed protein product

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Gene Aliases: AAG4; APO-J; APOJ; CLI; CLU1; CLU2; KUB1; NA1/NA2; SGP-2; SGP2; SP-40; TRPM-2

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UniProt ID: (Human) P10909

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Entrez Gene ID: (Human) 1191

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Function(s)
beta-amyloid binding receptor binding protein binding ATPase activity ubiquitin protein ligase binding macromolecular complex binding protein heterodimerization activity receptor agonist activity tau protein binding low-density lipoprotein particle receptor binding chaperone binding misfolded protein binding protein sequestering activity protein carrier chaperone
Process(es)
cell morphogenesis microglial cell activation release of cytochrome c from mitochondria negative regulation of activation of membrane attack complex immune complex clearance protein folding lipid metabolic process complement activation response to virus positive regulation of gene expression protein import negative regulation of protein complex assembly positive regulation of protein complex assembly central nervous system myelin maintenance positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of tumor necrosis factor production regulation of cell proliferation regulation of apoptotic process positive regulation of apoptotic process negative regulation of neuron apoptotic process reverse cholesterol transport positive regulation of nitric oxide biosynthetic process negative regulation of complement activation positive regulation of receptor-mediated endocytosis protein stabilization chaperone-mediated protein complex assembly response to misfolded protein microglial cell proliferation protein targeting to lysosome involved in chaperone-mediated autophagy negative regulation of release of cytochrome c from mitochondria intrinsic apoptotic signaling pathway beta-amyloid clearance regulation of beta-amyloid clearance positive regulation of beta-amyloid formation negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage negative regulation of beta-amyloid formation regulation of neuronal signal transduction positive regulation of neurofibrillary tangle assembly negative regulation of response to endoplasmic reticulum stress negative regulation of complement-dependent cytotoxicity negative regulation of amyloid fibril formation positive regulation of amyloid fibril formation positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of intrinsic apoptotic signaling pathway
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