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Invitrogen

CD51 (Integrin alpha V) Monoclonal Antibody (RMV-7), Biotin, eBioscience™

8 Published Figures
19 References
View all (35) Integrin alpha V (CD51) antibodies

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Product Details

13-0512-82

Applications
Tested Dilution
Publications

Immunohistochemistry (IHC)

-
View 2 publications 2 publications

Flow Cytometry (Flow)

1 µg/test
View 16 publications 16 publications

Functional Assay (Functional)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Mouse

Published species

Human, Mouse

Host/Isotype

Rat / IgG1, kappa

Recommended Isotype Control

Rat IgG1 kappa Isotype Control (eBRG1), Biotin, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

RMV-7

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_466477

Product Specific Information

Description: The RMV-7 monoclonal antibody reacts with the mouse CD51 molecule, the integrin alpha v chain. This approximately 120 kDa surface molecule non-covalently associates with the beta subunits of the integrin family including beta3 (CD61), beta1 (CD29), beta5 and beta6 to form receptors for extracellular matrix components. Heterodimers of CD51/CD61 are expressed by platelets, T cells and granulocytes and mediate adhesion to fibrinogen, fibronectin, vitronectin and thrombospondin.

Applications Reported: The RMV-7 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The RMV-7 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8, 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands, the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: alpha v integrin; unnamed protein product; vitronectin receptor alpha polypeptide (VNRA); vitronectin receptor subunit alpha

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Gene Aliases: 1110004F14Rik; 2610028E01Rik; CD51; D430040G12Rik

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UniProt ID: (Mouse) P43406

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Entrez Gene ID: (Mouse) 16410

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Function(s)
opsonin binding fibronectin binding protease binding protein kinase C binding receptor binding integrin binding protein binding coreceptor activity fibroblast growth factor binding C-X3-C chemokine binding insulin-like growth factor I binding signaling receptor activity neuregulin binding transforming growth factor beta binding extracellular matrix binding extracellular matrix protein binding
Process(es)
angiogenesis blood vessel development vasculogenesis inflammatory response cell adhesion cell-matrix adhesion positive regulation of cytosolic calcium ion concentration integrin-mediated signaling pathway positive regulation of cell proliferation fertilization negative regulation of macrophage derived foam cell differentiation negative regulation of lipid storage negative regulation of low-density lipoprotein particle clearance cell migration positive regulation of cell migration cell-substrate adhesion negative regulation of lipid transport detection of molecule of bacterial origin cell adhesion mediated by integrin positive regulation of osteoblast proliferation heterotypic cell-cell adhesion substrate adhesion-dependent cell spreading gonad morphogenesis wound healing, spreading of epidermal cells endodermal cell differentiation apolipoprotein A-I-mediated signaling pathway T cell activation apoptotic cell clearance endothelial cell migration regulation of bone resorption positive regulation of cell adhesion viral entry into host cell focal adhesion assembly negative regulation of lipoprotein metabolic process regulation of phagocytosis negative chemotaxis positive regulation of small GTPase mediated signal transduction release of sequestered calcium ion into cytosol trophoblast giant cell differentiation ERK1 and ERK2 cascade calcium ion transmembrane transport transforming growth factor beta production response to nitric oxide extrinsic apoptotic signaling pathway in absence of ligand cell-cell adhesion positive regulation of intracellular signal transduction negative regulation of entry of bacterium into host cell negative regulation of extrinsic apoptotic signaling pathway
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