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CD119 (IFN gamma Receptor 1) Monoclonal Antibody (2E2), Biotin, eBioscience™
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FIGURE: 1 / 7
CD119 (IFN gamma Receptor 1) Antibody (13-1191-82) in Flow
Staining of BALB/c splenocytes with 0.5 µg of Armenian Hamster IgG Isotype Control Biotin (Product # 13-4888-81) (blue histogram) or 0.5 µg of Anti-Mouse CD119 (IFN gamma Receptor 1) Biotin (purple histogram) followed by Streptavidin PE (Product # 12-4317-87). Total viable cells were used for analysis.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
13-1191-82
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Human,
Mouse
Host/Isotype
Armenian hamster
/ IgG
Recommended Isotype Control
Class
Monoclonal
Type
Antibody
Clone
2E2
Conjugate
Biotin
Biotin
Biotin
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Description: The monoclonal antibody 2E2 recognizes mouse CD119 also known as IFN gamma receptor1. CD119 heterodimerizes with IFN gamma receptor 2 (AF-1) forming the Class II cytokine receptor. The ligand IFN gamma binds IFN gamma receptor 1 subunit but signal transduction transpires via the IFN gamma receptor 2 subunit. The receptor is involved in host defense and expression is broad including B cells, NK cells, macrophages and dendritic cells as well as other non-hematopoietic cell types.
Applications Reported: This 2E2 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This 2E2 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: IFN-gamma receptor 1; IFN-gamma-R-alpha; IFN-gamma-R1; INF-g receptor; interferon gamma receptor alpha-chain; interferon gamma receptor precursor; interferon-gamma receptor; Interferon-gamma Receptor Antagonist; interferon-gamma receptor precursor; unnamed protein product
Gene Aliases: CD119; Ifgr; IFN-gammaR; Ifngr; Nktar
UniProt ID: (Mouse) P15261
Entrez Gene ID: (Mouse) 15979
microglial cell activation
immune system process
defense response
JAK-STAT cascade
response to virus
positive regulation of gene expression
cytokine-mediated signaling pathway
positive regulation of tumor necrosis factor production
type III interferon-mediated signaling pathway
astrocyte activation
defense response to virus
interferon-gamma-mediated signaling pathway
negative regulation of beta-amyloid clearance
positive regulation of beta-amyloid formation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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