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Invitrogen

CD130 (GP130) Monoclonal Antibody (AN-G30), Biotin, eBioscience™

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Product Details

13-1308-82

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-Dependent
-

Flow Cytometry (Flow)

0.125 µg/test
-

Immunoprecipitation (IP)

Assay-Dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Recommended Isotype Control

Mouse IgG2a kappa Isotype Control (eBM2a), Biotin, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

AN-G30

Conjugate

Biotin Biotin Biotin

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1907416

Product Specific Information

Description: The AN-G30 monoclonal antibody reacts with human gp130, also known as CD130. gp130 is the common receptor subunit for the IL-6 family of cytokines, including IL-6, IL-11, IL-27, Oncostatin M, and LIF. gp130 is expressed on numerous cell types, including T cells, mast cells, and epithelial cells. Soluble forms of gp130 have been isolated from human serum samples. Upon ligand binding, gp130 signals via the JAK-STAT, MAPK, and PI3 kinase pathways

Applications Reported: This AN-G30 antibody has been reported for use in flow cytometric analysis, immunoprecipitation, and immunoblotting (WB).

Applications Tested: This AN-G30 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD130 antigen; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130, oncostatin M receptor; GP130-RAPS; IL-6 receptor subunit beta; IL-6R subunit beta; IL6R-beta; interleukin receptor beta chain; interleukin-6 signal transducer; LIF receptor/IL-6 receptor complex component; membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin-M receptor subunit alpha; soluble receptor

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Gene Aliases: CD130; CDW130; GP130; HIES4; HIES4A; HIES4B; IL-6RB; IMD94; sGP130; STWS2

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UniProt ID: (Human) P40189

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Entrez Gene ID: (Human) 3572

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Function(s)
cytokine receptor activity ciliary neurotrophic factor receptor activity interleukin-6 receptor activity interleukin-11 receptor activity leukemia inhibitory factor receptor activity oncostatin-M receptor activity cytokine activity ciliary neurotrophic factor receptor binding interleukin-6 receptor binding protein binding coreceptor activity growth factor binding cytokine binding interleukin-11 binding interleukin-6 binding protein tyrosine kinase activator activity signaling receptor activity identical protein binding interleukin-27 receptor activity scaffold protein binding
Process(es)
negative regulation of cytokine-mediated signaling pathway positive regulation of acute inflammatory response positive regulation of adaptive immune response negative regulation of T-helper 1 type immune response inflammatory response JAK-STAT cascade cell proliferation positive regulation of cell proliferation positive regulation of vascular endothelial growth factor production positive regulation of cardiac muscle hypertrophy cytokine-mediated signaling pathway B cell differentiation megakaryocyte differentiation positive regulation of interleukin-10 production response to cytokine autocrine signaling paracrine signaling interleukin-11-mediated signaling pathway oncostatin-M-mediated signaling pathway positive regulation of T cell proliferation negative regulation of apoptotic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of osteoblast differentiation positive regulation of Notch signaling pathway leukemia inhibitory factor signaling pathway regulation of insulin secretion negative regulation of cytokine activity intestinal epithelial cell development interleukin-6-mediated signaling pathway negative regulation of interleukin-6-mediated signaling pathway interleukin-27-mediated signaling pathway ciliary neurotrophic factor-mediated signaling pathway negative regulation of fat cell proliferation T-helper 17 cell lineage commitment receptor signaling pathway via STAT positive regulation of platelet aggregation
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