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Proteintech
SLC22A2 Polyclonal Antibody
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Product Details
13594-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SLC22A2 Fusion Protein Ag4500 (39-150 aa encoded by BC039899)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GIVFLGFTP DHRCRSPGVA ELSLRCGWSP AEELNYTVPG PGPAGEASPR QCRRYEVDWN QSTFDCVDPL ASLDTNRSRL PLGPCRDGWV YETPGSSIVT EFNLVCANSW MLD (39-150 aa encoded by BC039899)
Target Information
Organic cation transporters (OCT) are expressed in the plasma membrane of epithelial cells from a wide range of tissues, where they function in the elimination of endogenous amines, cationic drugs and other xenobiotics. The structure of OCTs consists of a 12-transmembrane-domain structure and a large extracellular hydrophilic loop. In humans, OCT1 is primarily expressed in the liver, while OCT2 is expressed in the kidney. OCT3 is expressed in the placenta, skeletal muscle, prostate, aorta and liver. OCT2, also known as SLC22A2, is a multi-specific transporter protein localizing to the basolateral and luminal membranes of the kidney distal tubule and proximal tubules. OCT2 is responsible for mediating the pH-sensitive tubular uptake of organic compounds from circulation. An additional splice variant exists for OCT2, namely OCT2-A.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2-Oct; hOCT2; mOCT2; Organic cation transporter 2; rOCT2; solute carrier family 22 (organic cation transporter), member 2; Solute carrier family 22 member 2; solute carrier family 22, member 2; unnamed protein product
Gene Aliases: OCT2; OCT2r; Orct2; rOCT2; SLC22A2
UniProt ID: (Human) O15244, (Rat) Q9R0W2, (Mouse) O70577
Entrez Gene ID: (Human) 6582, (Rat) 29503, (Mouse) 20518
amine transmembrane transporter activity
acetylcholine transmembrane transporter activity
neurotransmitter transporter activity
monoamine transmembrane transporter activity
organic anion transmembrane transporter activity
organic cation transmembrane transporter activity
prostaglandin transmembrane transporter activity
L-amino acid transmembrane transporter activity
pyrimidine nucleoside transmembrane transporter activity
choline transmembrane transporter activity
thiamine transmembrane transporter activity
putrescine transmembrane transporter activity
efflux transmembrane transporter activity
spermidine transmembrane transporter activity
quaternary ammonium group transmembrane transporter activity
toxin transporter activity
transmembrane transporter activity
xenobiotic transporter activity
L-arginine transmembrane transporter activity
steroid binding
ion transmembrane transporter activity
transporter activity
secondary carrier transporter
ion transport
cation transport
neurotransmitter transport
serotonin transport
body fluid secretion
organic cation transport
quaternary ammonium group transport
prostaglandin transport
amine transport
putrescine transport
spermidine transport
acetylcholine transport
choline transport
dopamine transport
norepinephrine transport
xenobiotic transport
epinephrine transport
histamine transport
serotonin uptake
histamine uptake
norepinephrine uptake
transmembrane transport
thiamine transmembrane transport
purine-containing compound transmembrane transport
amino acid import across plasma membrane
dopamine uptake
L-arginine import across plasma membrane
export across plasma membrane
transport across blood-brain barrier
L-alpha-amino acid transmembrane transport
spermidine transmembrane transport
arginine transmembrane transport
cellular detoxification
drug transport across blood-brain barrier
ion transmembrane transport
cation transmembrane transport
transport
ammonium transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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