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Invitrogen
IL-20RB Monoclonal Antibody (20RNTC), eBioscience™
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FIGURE: 1 / 2
IL-20RB Antibody (14-1206-37) in ICC/IF
Immunofluorescent microscopy of fixed and permeabilized A375 cells using 10 µg/mL of Anti-Human/Mouse IL-20 Receptor 2 (IL-20Rb) Purified (right) or Rat IgG2a kappa Isotype Control Purified (Product # 14-4321-82) (left) followed by Anti-Rat IgG Biotin (Product # 13-4813-85) and then Streptavidin FITC (Product # 11-4317-87).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
14-1206-37
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rat
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
20RNTC
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
2 mg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Description: This 20RNTC monoclonal antibody recognizes mouse and human IL-20R2 (interleukin-20 receptor 2, IL-20Rb) in either of its two heterodimeric complexes formed by pairing with IL-20R1 or IL-22R1. IL-20R2 belongs to the class II cytokine receptor family that shares a characteristic pattern of cysteine, proline and tryptophan residues in the extracellular domain. IL-20R2 paired with IL-20R1 forms a receptor that binds IL-20, IL-19, or IL-24. IL-20R2 paired with IL22R1 forms a receptor that binds IL-20 or IL-24. The IL-20R complex signals primarily via the JAK-STAT pathway. IL-20R2 is found predominantly on cells of epithelial origin such as gut and skin and can be upregulated during inflammation. Immunofluorescent staining of A375 cells reveals a punctate staining pattern at the cell membrane, as well as diffuse, cytoplasmic staining that is likely associated with protein synthesis and transport in the endoplasmic reticulum and golgi.
Applications Reported: This 20RNTC antibody has been reported for use in immunocytochemistry, immunoblotting (WB) and flow cytometric analysis.
Applications Tested: This 20RNTC antibody has been tested by immunofluorescent staining and flow cytometric analysis of fixed and permeabilized A375 cells. This can be used between 1-10 µg/mL.
Purity: Greater than 90%, as determined by SDS-PAGE.
Aggregation: Less than 10%, as determined by HPLC.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009].
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: fibronectin type III domain containing 6; IL-20 receptor subunit beta; IL-20R2/IL-20rb; interleukin 20 receptor beta subunit; interleukin-20 receptor II; unnamed protein product
Gene Aliases: DIRS1; FNDC6; Gm186; IL-20R-beta; IL-20R2; IL-20RB; Il20R2
UniProt ID: (Human) Q6UXL0
Entrez Gene ID: (Human) 53833, (Mouse) 213208
apoptotic process
cytokine-mediated signaling pathway
osteoclast differentiation
negative regulation of interferon-gamma production
positive regulation of interleukin-13 production
positive regulation of interleukin-4 production
regulation of cell proliferation
cellular response to interleukin-4
dendritic cell differentiation
negative regulation of type IV hypersensitivity
inflammatory response to antigenic stimulus
immune response-inhibiting signal transduction
negative regulation of interleukin-2 production
positive regulation of interleukin-10 production
negative regulation of T cell proliferation
homeostasis of number of cells within a tissue
regulation of T cell activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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