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Proteintech
Synaptotagmin-1 Polyclonal Antibody
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Product Details
14511-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synaptotagmin-1 Fusion Protein Ag5970 (77-422 aa encoded by BC058917)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes endogenous SYT1, which has an experimentally determined molecular mass of 65-68 kDa. An additional band of 47 kDa could also be detected, which is corresponding to the calculated molecular weight of SYT1.
Immunogen sequence: FCICKKCLF KKKNKKKGKE KGGKNAINMK DVKDLGKTMK DQALKDDDAE TGLTDGEEKE EPKEEEKLGK LQYSLDYDFQ NNQLLVGIIQ AAELPALDMG GTSDPYVKVF LLPDKKKKFE TKVHRKTLNP VFNEQFTFKV PYSELGGKTL VMAVYDFDRF SKHDIIGEFK VPMNTVDFGH VTEEWRDLQS AEKEEQEKLG DICFSLRYVP TAGKLTVVIL EAKNLKKMDV GGLSDPYVKI HLMQNGKRLK KKKTTIKKNT LNPYYNESFS FEVPFEQIQK VQVVVTVLDY DKIGKNDAIG KVFVGYNSTG AELRHWSDML ANPRRPIAQW HTLQVEEEVD AMLAVKK (77-422 aa encoded by BC058917)
Target Information
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release. Studies indicate that synaptotagmin's Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane. It has been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Synaptotagmin 1 may have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Further, Synaptotagmin 1 binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has been reported. Synaptotagmin 1 can also bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Diseases associated with the dysfunction of Synaptotagmin 1 include food-borne botulism and infant botulism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp781D2042; FLJ42519; p65; SV DKFZp781D2042; SV SYT; Syb1; synaptotagmin 1; synaptotagmin 2; Synaptotagmin I; Synaptotagmin II; Synaptotagmin XI; Synaptotagmin-1; Synaptotagmin-2; SYT2; SytI; SytII; unnamed protein product
Gene Aliases: AW124717; BAGOS; G630098F17Rik; P65; SVP65; SYT; SYT1; SytI
UniProt ID: (Human) P21579, (Mouse) P46096
Entrez Gene ID: (Human) 6857, (Mouse) 20979
SNARE binding
phosphatidylserine binding
calcium ion binding
protein binding
calmodulin binding
phospholipid binding
calcium-dependent phospholipid binding
phosphatidylinositol-4,5-bisphosphate binding
lipid binding
syntaxin-1 binding
syntaxin binding
clathrin binding
syntaxin-3 binding
identical protein binding
metal ion binding
protein heterodimerization activity
calcium-dependent protein binding
low-density lipoprotein particle receptor binding
calcium ion sensor activity
molecular condensate scaffold activity
protein C-terminus binding
membrane trafficking regulatory protein
detection of calcium ion
vesicle fusion
chemical synaptic transmission
neurotransmitter secretion
regulation of dopamine secretion
vesicle organization
synaptic vesicle exocytosis
vesicle-mediated transport
regulation of exocytosis
regulation of calcium ion-dependent exocytosis
cell differentiation
regulation of vesicle fusion
positive regulation of vesicle fusion
positive regulation of dopamine secretion
positive regulation of calcium ion-dependent exocytosis
vesicle docking
calcium ion-regulated exocytosis of neurotransmitter
positive regulation of synaptic transmission
protein heterooligomerization
response to calcium ion
regulation of synaptic transmission, glutamatergic
spontaneous neurotransmitter secretion
cellular response to calcium ion
synchronous neurotransmitter secretion
fast, calcium ion-dependent exocytosis of neurotransmitter
calcium-dependent activation of synaptic vesicle fusion
membraneless organelle assembly
positive regulation of calcium ion-dependent exocytosis of neurotransmitter
regulation of regulated secretory pathway
positive regulation of dendrite extension
regulation of synaptic vesicle exocytosis
synaptic vesicle endocytosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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