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Proteintech
ATP1A2 Polyclonal Antibody
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Product Details
16836-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Dog,
Human,
Mollusc,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATP1A2 Fusion Protein Ag10515 (347-700 aa encoded by BC052271)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody was raised against the internal region of the human ATP1A2 and can recognize all the isoforms of alpha subunit. The 65 kDa band detected occasionally may be the degradation product of ATP1A2.
Immunogen sequence: KRMARKNCL VKNLEAVETL GSTSTICSDK TGTLTQNRMT VAHMWFDNQI HEADTTEDQS GATFDKRSPT WTALSRIAGL CNRAVFKAGQ ENISVSKRDT AGDASESALL KCIELSCGSV RKMRDRNPKV AEIPFNSTNK YQLSIHERED SPQSHVLVMK GAPERILDRC STILVQGKEI PLDKEMQDAF QNAYMELGGL GERVLGFCQL NLPSGKFPRG FKFDTDELNF PTEKLCFVGL MSMIDPPRAA VPDAVGKCRS AGIKVIMVTG DHPITAKAIA KGVGIISEGN ETVEDIAARL NIPMSQVNPR EAKACVVHGS DLKDMTSEQL DEILKNHTEI VFARTSPQQK LIIVE (347-700 aa encoded by BC052271)
Target Information
Atp1a2 encodes an Na+/K+ ATPase, which is a membrane protein that is composed of two subunits - alpha and beta. The Na+/K+ ATPase pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions. The Atp1a2 encoded protein belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These ion gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. The ATPase enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta), and the catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. The Atp1a2 gene encodes an alpha 2 subunit. Mutations in the Atp1a2 gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. Diseases associated with ATP1A2 include Alternating Hemiplegia Of Childhood and Migraine, Familial Hemiplegic, 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATPase Na+/K+ transporting alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 2; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ -ATPase alpha 2 subunit; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; Na+/K+ ATPase, alpha-B polypeptide; Na,K-ATPase subunit alpha-B; Sodium Potassium ATPase; Sodium pump subunit alpha-2; sodium-potassium ATPase catalytic subunit alpha-2; sodium/potassium-transporting ATPase alpha-2 chain; Sodium/potassium-transporting ATPase subunit alpha-2; unnamed protein product
Gene Aliases: ATP1A2; Atpa-3; AW060654; DEE98; FARIMPD; FHM2; KIAA0778; MHP2; mKIAA0778; RATATPA2
UniProt ID: (Human) P50993, (Rat) P06686, (Mouse) Q6PIE5
Entrez Gene ID: (Human) 477, (Rat) 24212, (Mouse) 98660
nucleotide binding
sodium:potassium-exchanging ATPase activity
steroid binding
protein binding
ATP binding
potassium-transporting ATPase activity
phosphatase activity
ATPase activity
cation-transporting ATPase activity
potassium ion binding
sodium ion binding
metal ion binding
protein heterodimerization activity
chaperone binding
steroid hormone binding
hydrolase activity
primary active transporter
neurotransmitter uptake
behavioral fear response
regulation of the force of heart contraction
regulation of respiratory gaseous exchange by neurological system process
ion transport
potassium ion transport
sodium ion transport
cellular sodium ion homeostasis
regulation of muscle contraction
regulation of smooth muscle contraction
regulation of striated muscle contraction
cell communication
blood circulation
regulation of heart contraction
regulation of blood pressure
adult locomotory behavior
visual learning
establishment or maintenance of transmembrane electrochemical gradient
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
response to auditory stimulus
neuronal action potential propagation
regulation of vasoconstriction
L-ascorbic acid metabolic process
amygdala development
olfactory cortex development
cellular cation homeostasis
cellular potassium ion homeostasis
response to nicotine
locomotory exploration behavior
sodium ion transmembrane transport
response to potassium ion
sodium ion export from cell
locomotion
fear response
negative regulation of heart contraction
positive regulation of heart contraction
negative regulation of striated muscle contraction
ATP metabolic process
negative regulation of cytosolic calcium ion concentration
membrane depolarization
regulation of glutamate uptake involved in transmission of nerve impulse
regulation of synaptic transmission, glutamatergic
relaxation of cardiac muscle
cardiac muscle contraction
cellular response to mechanical stimulus
cellular response to steroid hormone stimulus
potassium ion transmembrane transport
regulation of cardiac muscle cell contraction
membrane repolarization
membrane depolarization during cardiac muscle cell action potential
cell communication by electrical coupling involved in cardiac conduction
cation transmembrane transport
transport across blood-brain barrier
hydrogen ion transmembrane transport
negative regulation of calcium ion transmembrane transport
response to glycoside
potassium ion import across plasma membrane
metabolic process
potassium ion import
regulation of cardiac muscle contraction by calcium ion signaling
energy coupled proton transmembrane transport, against electrochemical gradient
ATP hydrolysis coupled proton transport
negative regulation of calcium:sodium antiporter activity
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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