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TTF-1 has been identified as a mediator of thyroid-specific gene transcription, and is involved in the activation of pulmonary-specific genes. TTF-1 is found in primary lung adenocarcinomas and small cell carcinomas. TTF-1 is usually absent in breast and colon carcinomas. TTF-1 monoclonal antibody should be useful in differentiating tumors of lung and non-lung origin. Lung cancer and thyroid gland tissues have been identified positive for TTF-1 monoclonal antibody concentrate.
TTF1 is a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BCH; BHC; NK-2; NK-2 homolog A; NKX2.1; NKX2A; RNA polymerase I termination factor; TEBP; TITF1; Transcription termination factor 1; Transcription termination factor I; transcription termination factor, RNA polymerase I; TTF-1; TTF-I
Gene Aliases: TTF-1; TTF-I; TTF1
UniProt ID: (Human) Q15361
Entrez Gene ID: (Human) 7270
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