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Invitrogen
Nkx2.1 Monoclonal Antibody (8G7G3/1)
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FIGURE: 1 / 3
Nkx2.1 Antibody (18-0221) in ICC/IF
International journal of molecular sciences 2019 -
Involvement of HIF-1alpha in alveolar epithelial cell phenotypic changes induced by hypoxia. Primary rat AECs were cultured in normoxia (Nx) (21% O 2 ) or hypoxia (Hx) (1.5% O 2 ) during 6 days in presence or absence of 10 uM YC-1. ( A ) Immunostaining of ZO-1 (magenta) and TTF1 (cyan) were performed. n = 4 experiments were performed. Isolated primary rat AECs were cultured in normoxia (Nx) (21% O 2 ) or hy... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
18-0221
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
Class
Monoclonal
Type
Antibody
Clone
8G7G3/1
Immunogen
Recombinant full length TTF-1 (Thyroid Transcription Factor 1) protein
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Purification
purified
Storage buffer
PBS with 1% BSA
Contains
0.1% sodium azide
Storage conditions
2-8°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
TTF-1 has been identified as a mediator of thyroid-specific gene transcription, and is involved in the activation of pulmonary-specific genes. TTF-1 is found in primary lung adenocarcinomas and small cell carcinomas. TTF-1 is usually absent in breast and colon carcinomas. TTF-1 monoclonal antibody should be useful in differentiating tumors of lung and non-lung origin. Lung cancer and thyroid gland tissues have been identified positive for TTF-1 monoclonal antibody concentrate.
Target Information
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: homeobox protein NK-2 homolog A; NK-2 homolog A; thyroid nuclear factor 1; thyroid transcription factor 1; thyroid-specific enhancer-binding protein; TTF1
Gene Aliases: BCH; BHC; NK-2; NKX2.1; NKX2A; NMTC1; T/EBP; TEBP; TITF1; TTF-1; TTF1
UniProt ID: (Human) P43699
Entrez Gene ID: (Human) 7080
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
intronic transcription regulatory region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
enzyme binding
sequence-specific DNA binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
brain development
response to hormone
gene expression
positive regulation of gene expression
negative regulation of epithelial to mesenchymal transition
globus pallidus development
hypothalamus development
cell differentiation
lung development
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
thyroid gland development
forebrain development
positive regulation of circadian rhythm
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
animal organ development
epithelial tube branching involved in lung morphogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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