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Invitrogen
Cytokeratin 5/6 Monoclonal Antibody (D5/16B4)
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Product Details
18-0267
Product Specifications
Host/Isotype
Mouse
Class
Monoclonal
Type
Antibody
Clone
D5/16B4
Immunogen
Purified Cytokeratin 5 and 6
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.05 mg/mL
Amount
50 µg
Storage conditions
2-8°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This monoclonal antibody reacts with Cytokeratin 5/6, and reacts weakly with Cytokeratin 4. It stains the basal cells of squamous and glandular epithelia, part of stratum spinosum of squamous epithelium, myoepithelium, and mesothelium. It does not stain adenous epithelium. Therefore, this antibody can be used to distinguish squamous carcinoma from adenocarcinoma, and to differentiate epitheloid mesothelioma from non-epitheliod mesothelioma and adenocarcinoma. It is also a useful antibody to distinguish benign ductal hyperplasias from non-invasive neoplastic proliferations. Positive tissue: Skin.
Expected Staining Pattern: Cytoplasmic
Target Information
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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