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Rockland
NF-Y Polyclonal Antibody
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Product Details
200-401-101
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NF-Y (B subunit) peptide corresponding to a region near the N-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Ion-exchange chromatography
Storage buffer
0.01M sodium phosphate, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
This product was prepared from monospecific antiserum by a multi-step procedure which includes delipidation, salt fractionation and ion exchange chromatography. A single precipitin arc was observed against anti-Rabbit Serum when assayed by immunoelectrophoresis.
Target Information
The NFYA gene encodes for one of the subunits of the Nuclear Factor Y (NF-Y) transcription factor, which plays a critical role in the regulation of various genes, particularly those containing the CCAAT box within their promoter regions. Structurally, NF-Y consists of a heterotrimeric complex made up of NF-YA, NF-YB, and NF-YC subunits. NF-YA serves as the sequence-specific DNA-binding component, whereas the NF-YB/NF-YC heterodimer forms a Histone Fold Domain crucial for DNA binding and stabilization. Functionally, NF-YA is pivotal in cell cycle regulation and neuronal development, influencing neural progenitor maintenance during brain morphogenesis. It has been implicated in various physiological processes, including response to plant stress and cancer progression. Specifically, NFYA gene activity is prevalent in proliferating cells and is often dysregulated in cancerous tissues, which highlights its potential as a therapeutic target. NFYA's expression in plant systems, such as in the Arabidopsis species, is modulated by environmental stresses like drought, indicating its broader impact on biological stress responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAAT box DNA-binding protein subunit A; CAAT-box DNA binding protein subunit A; CCAAT-binding transcription factor subunit B; FLJ11236; HAP2 CCAAT-binding protein; nf-y; NF-YA; NFYA transcript; Nuclear transcription factor Y subunit A; Nuclear transcription factor Y subunit alpha; nuclear transcription factor Y, alpha; transcript variant 1; Transcription factor NF-Y, A subunit
Gene Aliases: CBF-A; CBF-B; HAP2; NF-YA; NFYA
UniProt ID: (Human) P23511
Entrez Gene ID: (Human) 4800
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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