Thermo Scientific Pierce DST, also called disuccinimidyl tartrate, is a water-soluble crosslinker that contains amine-reactive NHS ester ends around a 4-atom spacer arm, whose central diol can be cleaved by periodate oxidation.

Features of disuccinimidyl tartrate:

• Reactive groups: NHS ester (both ends)
• Reactive towards: amino groups (primary amines)
• Soluble in DMSO or DMF at a concentration of ∼10 mM (3 mg/mL)
• Cleavable by sodium meta-periodate (Part No. 20504)
• Ideal for applications in which crosslink cleavability is desired without disturbing protein disulfide bonds

Product References:

Crosslinker Application Guide -- search for recent literature references for this product

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DST (disuccinimidyl tartrate)