Thermo Scientific Pierce DST, also called disuccinimidyl tartrate, is a water-soluble crosslinker that contains amine-reactive NHS ester ends around a 4-atom spacer arm, whose central diol can be cleaved by periodate oxidation.
Features of disuccinimidyl tartrate:
•
Reactive groups: NHS ester (both ends)
•
Reactive towards: amino groups (primary amines)
• Soluble in DMSO or DMF at a concentration of ∼10 mM (3 mg/mL)
• Cleavable by
sodium meta-periodate (Part No. 20504)
• Ideal for applications in which crosslink cleavability is desired without disturbing protein disulfide bonds
Product References:
Crosslinker Application Guide -- search for recent literature references for this product
Related ProductsDST (disuccinimidyl tartrate)
